Gene Ontology annotation through association of InterPro records with GO terms.
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.
INCORRECT ANNOTATION - This pathway confuses PLD4 with PLCD4. PLD4 does not hydrolyze PI(4,5)P2.
PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing
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Demonstrates that PLD3 and PLD4 are 5'-3' exonucleases that degrade ssDNA in endolysosomes, regulating TLR9 activation.
"they are 5' exonucleases, probably identical to spleen phosphodiesterase, that break down TLR9 ligands"
Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4.
PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes.
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Discovers that PLD4 synthesizes S,S-BMP via transphosphatidylation.
"we report that phospholipases D3 and D4 (PLD3 and PLD4) synthesize lysosomal S,S-BMP"
Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia.
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Demonstrates PLD4 expression in microglia and spleen, shows lack of PLD enzymatic activity, and localizes PLD4 to ER and Golgi.
"heterologously expressed PLD4 proteins did not exhibit PLD enzymatic activity"
Deep research review of PLD4 function
Cyberian deep research on PLD4 function