The review preserves 150 genuine seed rows covering 151 TSV rows and all 152 original QuickGO contexts. Stored decisions are 25 ACCEPT, 100 KEEP_AS_NON_CORE, 11 MODIFY, 7 UNDECIDED, 2 MARK_AS_OVER_ANNOTATED and 5 TOO_GENERAL. Original-context counts are 26 ACCEPT, 101 KEEP_AS_NON_CORE, 11 MODIFY, 7 UNDECIDED, 2 MARK_AS_OVER_ANNOTATED and 5 TOO_GENERAL. There are three unchanged natural products, two cores, and no NEW annotations or supporting-text quotations. Evidence synthesis records biological and access boundaries.
Two source collapses are retained rather than repaired by hand. The source TSV and seeded machine fields are not edited. The original JSON contexts remain in the reproducible private projection proof; their original identifiers, assigners and extension differences are preserved below.
| Stored index (zero-based) | Raw index | QuickGO ID | Assigning database | Reference | Extensions |
| --- | --- | --- | --- | --- | --- |
| 87 | 78 | UniProtKB:P21333!387295863 | BHF-UCL | PMID:10051605 | null |
| 87 | 79 | UniProtKB:P21333!387295864 | ComplexPortal | PMID:10051605 | null |
| 127 | 144 | UniProtKB:P21333!387295929 | UniProt | PMID:20458337 | null |
| 127 | 145 | UniProtKB:P21333!387295930 | UniProt | PMID:20458337 | [{"connectedXrefs":[{"db":"CL","id":"0000639","relation":"part_of"}]}] |
The two actin-organization contexts share a seed decision after source-key projection. The two exosome contexts share one exported TSV and seed row even though only one original JSON context carries its cellular extension. Neither context is discarded scientifically, and no duplicate NEW row is manufactured.
The exporter does not represent these structured extensions in its 16-column TSV. They remain source assertions, not edits or additional annotations. An extension question is distinguished from the validity of its main binding/location term.
| Raw index | QuickGO ID | Reference | Original structured extension |
| --- | --- | --- | --- |
| 12 | UniProtKB:P21333!387295797 | PMID:12393796 | [{"connectedXrefs":[{"db":"GO","id":"0005737","relation":"occurs_in"}]}] |
| 19 | UniProtKB:P21333!387295804 | PMID:16862148 | [{"connectedXrefs":[{"db":"GO","id":"0005642","relation":"occurs_in"}]}] |
| 47 | UniProtKB:P21333!387295832 | PMID:28297718 | [{"connectedXrefs":[{"db":"GO","id":"0005634","relation":"occurs_in"}]}] |
| 48 | UniProtKB:P21333!387295833 | PMID:30021884 | [{"connectedXrefs":[{"db":"GO","id":"0005634","relation":"occurs_in"}]}] |
| 129 | UniProtKB:P21333!387295914 | PMID:21423176 | [{"connectedXrefs":[{"db":"CL","id":"0000057","relation":"part_of"}]}] |
| 54 | UniProtKB:P21333!387295839 | PMID:24951510 | [{"connectedXrefs":[{"db":"UniProtKB","id":"Q9H2S1","relation":"has_input"}]}] |
| 85 | UniProtKB:P21333!387295870 | PMID:15684392 | [{"connectedXrefs":[{"db":"UniProtKB","id":"P40424-1","relation":"has_input"}]}] |
| 59 | UniProtKB:P21333!387295844 | PMID:24951510 | [{"connectedXrefs":[{"db":"UBERON","id":"0000948","relation":"occurs_in"}]}] |
| 143 | UniProtKB:P21333!387295928 | PMID:19056867 | [{"connectedXrefs":[{"db":"UBERON","id":"0001088","relation":"part_of"}]}] |
| 145 | UniProtKB:P21333!387295930 | PMID:20458337 | [{"connectedXrefs":[{"db":"CL","id":"0000639","relation":"part_of"}]}] |
| 146 | UniProtKB:P21333!387295931 | PMID:21362503 | [{"connectedXrefs":[{"db":"CL","id":"0002367","relation":"part_of"}]}] |
| 98 | UniProtKB:P21333!387295883 | PMID:24951510 | [{"connectedXrefs":[{"db":"UniProtKB","id":"Q9H2S1","relation":"has_input"}]}] |
| 70 | UniProtKB:P21333!387295855 | PMID:17536008 | [{"connectedXrefs":[{"db":"UniProtKB","id":"P35462","relation":"has_input"}]}] |
| 105 | UniProtKB:P21333!387295890 | PMID:24951510 | [{"connectedXrefs":[{"db":"CL","id":"0002495","relation":"occurs_in"}]}] |
All 64 publication records below were genuinely fetched or reused exactly from qualified main. Thirty-eight pre-existing normal sources across publications/Reactome/family scope were hydrated and hash-verified before fetch and remain unchanged. The 35 absent normal paths were acquired only within the qualified scope. The normal cache flag is reported as metadata, not a claim that all Methods, supplements or target tables were inspected. Detailed primary-reading limits accompany the annotation reasons and evidence synthesis.
| Reference | Normal cache full-text flag | Cache SHA256 |
| --- | --- | --- |
| PMID:1833070(https://pubmed.ncbi.nlm.nih.gov/1833070/) | false | c45bad68efcd07ae155aaad46310301cc8e038b4d0cd075973eda373d871575d |
| PMID:2391361(https://pubmed.ncbi.nlm.nih.gov/2391361/) | false | ae124f18dcf36a5fb97c44585312de9e517a60a534da383c632675c525270d11 |
| PMID:3138234(https://pubmed.ncbi.nlm.nih.gov/3138234/) | false | f352382112d672f0dbe1ddeee8c2454461b890799f55ab44825be6b0b39d9d56 |
| PMID:4044584(https://pubmed.ncbi.nlm.nih.gov/4044584/) | false | 505fedfb0a98c7060dd637cf63b43a83b9dee274cbe3d2ce17fb9989abb867b1 |
| PMID:9722563(https://pubmed.ncbi.nlm.nih.gov/9722563/) | false | c16d76abc2d8f2d2cee4175948c7eea5306c31f92ae1f45e77359d36d2a05be8 |
| PMID:10051605(https://pubmed.ncbi.nlm.nih.gov/10051605/) | false | e54c38e64c2746fecdbbf256f8e7d62d2bca75ff2c59d6753784813b663c4208 |
| PMID:10604475(https://pubmed.ncbi.nlm.nih.gov/10604475/) | false | e5f6236ed885476b3bed5cd639eb16f1a1e0fc36f58e5345f33b87730346b851 |
| PMID:10692483(https://pubmed.ncbi.nlm.nih.gov/10692483/) | false | 6a5312209ee050c363f31dd0b51d1366a203b11987990099df2e75484f97e89a |
| PMID:12393796(https://pubmed.ncbi.nlm.nih.gov/12393796/) | false | fb8bfb9dec982f3603ef41b2a1aea4f5b9de7f7288b8cff11666c16a1ceeb75b |
| PMID:12577067(https://pubmed.ncbi.nlm.nih.gov/12577067/) | false | a14f9750c78006e26303c1f77bb88044d056ba71269c470d394d2d169d59dae5 |
| PMID:12761501(https://pubmed.ncbi.nlm.nih.gov/12761501/) | false | 845d6cef9ec6e22c299a9934c487ec116386f21a8dc8b4401893a6256c7be609 |
| PMID:14573758(https://pubmed.ncbi.nlm.nih.gov/14573758/) | false | e0a19258c3a0243b53364ceda02fbba20a7c9f3e360c06f873f2a7f98ffed25f |
| PMID:15661894(https://pubmed.ncbi.nlm.nih.gov/15661894/) | false | e4e05fc897b012d186a12fa3d8c7fdf0feaf3223e38693ea47dc701f96d67ec8 |
| PMID:15684392(https://pubmed.ncbi.nlm.nih.gov/15684392/) | false | e286958bf306cb3a95866de516729260c991e75684734a977407d0d29744d8b3 |
| PMID:16076904(https://pubmed.ncbi.nlm.nih.gov/16076904/) | false | b63ef493d8f7b666f625c5d5751fb7d9140240f76323eef6e4b5b970951ffede |
| PMID:16291724(https://pubmed.ncbi.nlm.nih.gov/16291724/) | false | 07136e1f7d5178ccee7fe9701e0a4cb34faf8611ef4e5cc638b1d777f995b1b6 |
| PMID:16293600(https://pubmed.ncbi.nlm.nih.gov/16293600/) | false | 271feb41d7d437ffa5a4eaf72aecebee8173014dba2bac45d820b1e0a8e7dccc |
| PMID:16862148(https://pubmed.ncbi.nlm.nih.gov/16862148/) | false | f5b6b79a036aa8c51245ca908f97256519587330a91cc4f47afc5330c94c4fc9 |
| PMID:17408621(https://pubmed.ncbi.nlm.nih.gov/17408621/) | false | 0a3405f416979d3ce7ead0fd0b4d732b169ad5b10de3b4770cdc3f5865b2ae4f |
| PMID:17474147(https://pubmed.ncbi.nlm.nih.gov/17474147/) | false | c3fdff162d5aad9393123ae3de2f041784929f80054b8b7eeb28ef6487851872 |
| PMID:17536008(https://pubmed.ncbi.nlm.nih.gov/17536008/) | false | 7c302497772644014f4a00d7049e36b37896fd2665da0ab630bfd0f910cbbcb2 |
| PMID:17690686(https://pubmed.ncbi.nlm.nih.gov/17690686/) | true | c370b4a02921ab54e2fd8082f6c164f938dc12941f72298a21c4145ebc64f1fb |
| PMID:18177638(https://pubmed.ncbi.nlm.nih.gov/18177638/) | false | d0a6a01640b0befcdab03156bf0c1b015944d49c3f428bd7869c096c1e53393f |
| PMID:18322202(https://pubmed.ncbi.nlm.nih.gov/18322202/) | false | 3f86b62d4fd442a2fa837f5267954e8fafb9f70defe4b42e162254483cd674ba |
| PMID:18548008(https://pubmed.ncbi.nlm.nih.gov/18548008/) | false | 5d7b05abb51287de0bd1cecef8f575337463898a4be72dcbc3aff1c191a121ee |
| PMID:19056867(https://pubmed.ncbi.nlm.nih.gov/19056867/) | false | 90ceb930bcd3ba708af5c0630dfcc028133affae4b73bd0409c758d54b43f2c4 |
| PMID:19828450(https://pubmed.ncbi.nlm.nih.gov/19828450/) | false | e5dd1d8620bcbf6dbb9b593b55022a6930996d91f751f945e1aa235f2eb6e94a |
| PMID:19946888(https://pubmed.ncbi.nlm.nih.gov/19946888/) | false | 27bc1721cb6463979e40a01e57a8f855a881db7d5cce684165492ecd4d6f2337 |
| PMID:20167606(https://pubmed.ncbi.nlm.nih.gov/20167606/) | true | 0a445597effbeb56b425ca38e0e02edec0491b0545dbb1faa13c11f0af38e8c3 |
| PMID:20236936(https://pubmed.ncbi.nlm.nih.gov/20236936/) | true | 5b570386ec9772ec4c783a10504f53029c404bd84dbb2d61d4a7af3d05dba537 |
| PMID:20458337(https://pubmed.ncbi.nlm.nih.gov/20458337/) | false | 82cfcf11808cf3424b9b39a17b24c4b221010856f9cc70d6e63fcc523a7591d2 |
| PMID:20713593(https://pubmed.ncbi.nlm.nih.gov/20713593/) | true | 37d853d64bba2f64745b979b2e18ef3c0324782588b0117cb15f258b58ba91ab |
| PMID:21228480(https://pubmed.ncbi.nlm.nih.gov/21228480/) | false | 003400784088e4bebd5821cb448faff6f4dc480bae48e0fbfe149e7879c13367 |
| PMID:21362503(https://pubmed.ncbi.nlm.nih.gov/21362503/) | true | 58f7dbcc96c54d80adfff4e03d452a9a6adb5525153a0746f273a6cb10cca5dd |
| PMID:21423176(https://pubmed.ncbi.nlm.nih.gov/21423176/) | true | b07fc29f18f0735f07a19d469e7bdf8ba7f71a211f3b6f423f91e3dfc6170847 |
| PMID:21524097(https://pubmed.ncbi.nlm.nih.gov/21524097/) | true | 1e8ca4622f0f735a587a378b57ab8b8e8ea73d69dfa240157936484274507de4 |
| PMID:21653829(https://pubmed.ncbi.nlm.nih.gov/21653829/) | true | 5ba079e7f82460fdf277f904e70f430d236c66c27eee83391374c931cd7c75dd |
| PMID:21914078(https://pubmed.ncbi.nlm.nih.gov/21914078/) | false | 513f9e14686858c453c535b837d90fe2b078832b04befb5773fca78f318d10d7 |
| PMID:21926999(https://pubmed.ncbi.nlm.nih.gov/21926999/) | true | a0fc494399c6a022b3173bf24fd71d26b5e7caf5aa228ff06f4a8b7507bfff6f |
| PMID:22076441(https://pubmed.ncbi.nlm.nih.gov/22076441/) | false | 8ca9f075d411606e55402ab65d611e9ccd91ed641f0191d56e7dc72ea561f12b |
| PMID:22121117(https://pubmed.ncbi.nlm.nih.gov/22121117/) | false | 6c7ede80de1f6472ee1295d90dc40820b166709658cdcc236a4d8689e172b9a9 |
| PMID:22307607(https://pubmed.ncbi.nlm.nih.gov/22307607/) | false | 523e018b1e0b1bf1735d024c903943228ee92720539b7bce1f576027ffce80e1 |
| PMID:22434607(https://pubmed.ncbi.nlm.nih.gov/22434607/) | true | a23b3a56d533e9374367fd47d1b5f8a2c5678f35caca51e56d0c574af67aa1eb |
| PMID:22658674(https://pubmed.ncbi.nlm.nih.gov/22658674/) | false | 0b517b543457b4dfdaeb08be8018639eae51a57a06945c05bb5e4252888cead3 |
| PMID:22681889(https://pubmed.ncbi.nlm.nih.gov/22681889/) | false | e3956394916d14a4ecb0b4f8fc9f3bfdcc7fc18cfa99a4c6b9538a6f31a5ebd6 |
| PMID:22872576(https://pubmed.ncbi.nlm.nih.gov/22872576/) | false | 02eecfe11536ed222f59010220d88443336c3053667379137a6c15d989d759d1 |
| PMID:22948144(https://pubmed.ncbi.nlm.nih.gov/22948144/) | false | 56acf09ee850326fc37c6c9ce0a39b768529b14809c86f8cc25bc71f10c6d113 |
| PMID:23382103(https://pubmed.ncbi.nlm.nih.gov/23382103/) | true | 37869b7a9cd5ac99b5783c6be4a0ed04484076bedb8223eb81078f24c3635b1d |
| PMID:23525008(https://pubmed.ncbi.nlm.nih.gov/23525008/) | true | d1e0249d2d8ab67df54c08f04f429fd0fbb292394af840b897db87600d5ba689 |
| PMID:23533145(https://pubmed.ncbi.nlm.nih.gov/23533145/) | true | f347293c23617bd56d83e1ae9bc3ad8a65e540fdbf4aff13bd0e918ec598a17e |
| PMID:24021649(https://pubmed.ncbi.nlm.nih.gov/24021649/) | true | a06c1e29183e39a54ac7f6401b9be78c7d91874ea3e08176a5a9acd28487c132 |
| PMID:24951510(https://pubmed.ncbi.nlm.nih.gov/24951510/) | true | bc0263c0fbf428518d8cd994ed9195a88a6a68397a8471f948e28c42fead6ecd |
| PMID:25241761(https://pubmed.ncbi.nlm.nih.gov/25241761/) | false | e596792fcdc8dcc94dcd7750af0a78b32ad1e339cdfe116b8fcff4295727ff47 |
| PMID:25358863(https://pubmed.ncbi.nlm.nih.gov/25358863/) | false | da8641c7d77438eac860ffe7a384aa4890a3da0443f62910d3e2dc541e57c48d |
| PMID:25468996(https://pubmed.ncbi.nlm.nih.gov/25468996/) | true | c0fe6902adfa6272ca0a1676f2125d6976d98122771aa2322ffd9bb6d4b549e0 |
| PMID:25666618(https://pubmed.ncbi.nlm.nih.gov/25666618/) | true | ee94bbe5740e84b025c6183cf86037b745d4d7527b61bca0c80558e9fb9eb1f5 |
| PMID:25849143(https://pubmed.ncbi.nlm.nih.gov/25849143/) | true | 65417cb16edda696824f67269e4afd2a7821d77987296ba20c82570a5d437689 |
| PMID:26157139(https://pubmed.ncbi.nlm.nih.gov/26157139/) | false | fac651d5fd6623fc5cd4186a7b4634b2bcbb46c58ec8fc84a3b0d6f350bce9e4 |
| PMID:26460884(https://pubmed.ncbi.nlm.nih.gov/26460884/) | true | 7d5194b6910c3c470fa7ccd37953ab5ec50a4347da5c5aa82bce40c43fdf782e |
| PMID:26496610(https://pubmed.ncbi.nlm.nih.gov/26496610/) | false | f33c29fb4324f617e58cef04e408bb14674baffd3fe8ccb65f48fa4fa5e391a2 |
| PMID:26972007(https://pubmed.ncbi.nlm.nih.gov/26972007/) | true | a77370cfcb9bc0a303a2edf4c5ed47b965cc2336f3450bdc36a0a7c7a7bd46b3 |
| PMID:28297718(https://pubmed.ncbi.nlm.nih.gov/28297718/) | true | 869778539f0669c206199940beb88de1cebf6c51aad1a83aa8e91a7819fa64e9 |
| PMID:30021884(https://pubmed.ncbi.nlm.nih.gov/30021884/) | true | 37dcd64f8c58bf30bb7072f41859fc4658ddba2a2cc7db026c56447b874777b1 |
| PMID:36577757(https://pubmed.ncbi.nlm.nih.gov/36577757/) | true | 9db38d0500c3d58df592069ee1660d035039127824d4559cb39d0ffdd27ed948 |
Complete official PTHR38537 tree: 297 nodes; SHA256 c4ac6ebf6fa68e9355115a5bfb860eea395f3aeb15acfa238cb796cb7365a466. Original IBD SHA256 0c672914e10c1f79d3fb365077d843a92e518eb6eee2aac00c67150274adf569. The repository parser and serializer produced the one-row normal PAINT source SHA256 81bace123a0fd1cea473868e21271eee8330bc086cd8ae7752ce0bdac04e9661. PTN002213724 is outside the FLNA target path and no incoming FLNA IBA is present. All-family intersection was used; no bulk leaf-GAF archive was downloaded and no empty source was fabricated.
Official source: https://pantherdb.org/services/oai/pantherdb/treeinfo?family=PTHR38537 . The pinned original IBD source URL is https://data.pantherdb.org/ftp/downloads/paint/current/IBD.gaf.
Cytosol/cortex-to-cytoplasm and actin-cytoskeleton-to-cytoskeleton is_a/part_of paths support the five TOO_GENERAL resolution decisions, including plasma membrane is_a membrane. The Myb-complex nuclear ancestry and intrinsic-coagulation definition support the two term-scope overannotations. Exact current term responses and relation paths were saved during the independent primary consultations; no missing ontology edge is treated as proof of biological disjointness.
The private source/context proof pins the genuine seed, complete original QuickGO response, authoritative 152-row review matrix, all 73 normal sources and their main/reuse disposition. It verifies all non-review fields and row order against the seed and preserves both collapsed source groups. Validation checks are scoped to the gene, reference objects, strict GOA comparison, authored ontology terms, append-only history and a private HTML render. Status remains DRAFT because of unresolved assertions and the disclosed generic-binding advisories. No inference of universal isoform function, no new quotation and no speculative new process annotation is made.
The actin-binding/crosslinking core is unchanged. The added protein-macromolecule adaptor core uses the already-qualified PMID:21926999 reconstituted actin-network/integrin-tail experiments and PMID:17690686 human FLNA-repeat evidence. Official ontology paths distinguish this activity from actin filament binding. Selected original Results and main-text Methods were re-read; no supplementary species/production protocol or figure-pixel audit is claimed.
Stored row100/raw86 retains contextual mRNA transcription by RNA polymerase II based on the PMID:20167606 FLNA–Smad scaffold/shuttle and promoter-association experiments. Stored row133/raw99 retains tubulin deacetylation based on PMID:26157139 interaction interference, local HDAC5 accumulation and deacetylation measurements. The source evidence synthesis records the distinct human, rat and mouse systems and the unresolved mechanistic limits. All original actions, source objects, products, source hashes and deterministic context mappings remain unchanged; no source was newly acquired and no quotation was added.
Stored rows 6–9 / raw 5–8 are refined to GO:0031267, rows 11/12/15 / raw 10/11/14 to GO:0001664, row 16 / raw 15 to GO:0140297, and row 27 / raw 26 to GO:0034988. Exact original evidence codes, partner accessions, references and qualifiers remain unchanged. The separate specific source records are conserved. The evidence synthesis records the positive assays and retained purity, species, construct and source-access limits for each group.
Fresh official QuickGO term/ancestor responses confirm that each replacement is an is_a descendant of GO:0005515; the linked term pages provide the definitions. Selected original PMID:10051605 Methods/Results and PMID:17536008 human D3 Methods/Results were re-read. Indexed official PMID:15684392 Methods/Results/Fig1 text confirms the NPCE/HeLa and mouse C2C12 distinction; direct PMC HTML still returned a challenge, so no new downloaded full-body or figure-pixel audit is claimed. Original PMID:10692483 and PMID:14573758 were read at authentic-abstract level. The D3-specific PMID:10692483 assay remains unrecovered and is distinguished from PMID:17536008 corroboration. No normal publication cache was changed or newly acquired.
The prior two-process/adaptor-core follow-up remains scientifically unchanged. The preceding nine-row action refinement yielded 39 generic-binding advisories, with the unmirrored-adaptor-core advisory still disclosed after validation. All 150 stored source objects and 152 original contexts remain represented, with three unchanged natural products, two unchanged cores and no new annotation or quotation.
Stored row17/raw16 (UniProtKB:P21333!387295801; partner Q9NP98/MYOZ1) now uses MODIFY GO:0051373 FATZ binding. Stored row18/raw17 (UniProtKB:P21333!387295802; partner Q9UBF9/MYOT) now uses MODIFY GO:0008092 cytoskeletal protein binding. Both retain their original PMID:16076904 IPI records and partners. The original abstract explicitly includes FLNA in the reported binding to both proteins; the specific partner classes are supported without guessing an interface or assigning partner functions to FLNA.
The evidence synthesis distinguishes these abstract-supported refinements from unavailable FLNA-specific assay/construct detail and from FLNC interface mapping. All 73 accepted normal sources were reused as exact main bytes. The other 148 review objects, three natural products, two cores, 78 references, original extensions and 152-to-150 projection are unchanged. There are now 37 generic-binding NC assertions; the unmirrored-adaptor-core advisory remains. No new annotation, quotation or gene-completion credit is introduced.
GO:0008092 is accepted as redundant in the gene-level deduplicated term set because actin filament binding is its descendant. The retained MYOT row serves a different evidential purpose: it preserves the PMID:16076904 interaction with Q9UBF9, which actin-binding evidence alone does not establish. The original partner/source record remains explicit; no additional core function or NTR is introduced.
The unchanged UniProt FLNA record, CC:INTERACTION line923, associates P21333-2 with Q9NP98/MYOZ1 and reports six experiments with IntAct EBI-9641086/EBI-744402. This is curated corroboration for the isoform-2 pair, not proof of an independent publication, exclusivity to isoform2, or binding by every natural product. The specific experiments underlying that aggregate were not newly replayed. The same record's CC:SUBUNIT (line833) also names MYOT and MYOZ1, and its reference18/RP (lines233–234) attributes their interactions to PMID:16076904. Absence of a dedicated MYOT row in the CC:INTERACTION pair table is therefore not absence of a UniProt MYOT assertion; the RP repeats the same paper and is not independent primary support. No source, reference object, record-section backfill or quotation is added.
The earlier history links PR5708 as the provenance of the reviewed FLNA record. A new append-only EDIT history links the current PR5715; the already committed histories remain unchanged.