Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Combined Automated Annotation using Multiple IEA Methods
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.
Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells.
The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A.
Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins.
Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays.
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Networks of bZIP protein-protein interactions diversified over a billion years of evolution.
Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Architecture of the human interactome defines protein communities and disease networks.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
Multimodal cell maps as a foundation for structural and functional genomics.
XPO1:BACH1:Hemes are transported out of the nucleus
XPO1 (CRM1) binds to BACH1:Hemes
p-Y483 BACH1 translocates from the nucleoplasm to the cytosol
BACH1 gene produces BACH1
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))
BACH1:FBXL17 binds SCF(SKP2) complex
BACH1 translocates from the cytosol to the nucleoplasm
BACH1 is phosphorylated at tyrosine 483
Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1.
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene.
Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1.
Heme induces ubiquitination and degradation of the transcription factor Bach1.
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.
Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter.
Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.
Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress.
UniProtKB/Swiss-Prot entry O14867 (BACH1_HUMAN)