gpr-2 review notes
- Fetch:
just fetch-gene worm gpr-2 failed repeatedly with a read timeout on the UniProt
gene-symbol stream search (a direct curl of that search also timed out at 90 s, while the
accession endpoint answered in <1 s). Ran just fetch-gene worm Q03569 --alias gpr-2;
confirmed id Q03569 (GPR2_CAEEL, gene gpr-2 / C38C10.4), 13 GOA rows.
- No deep-research provider available; literature compiled manually in
gpr-2-deep-research-manual.md.
- All functional data are for GPR-1/2 jointly (near-identical paralogs; RNAi/antibodies
cross-react) PMID:16247027. Statements about GPR-1/2 are treated as applying to gpr-2, as
WormBase and ComplexPortal curators do. Kept consistent with the gpr-1 review
(genes/worm/gpr-1/gpr-1-ai-review.yaml).
- PMID:16247027 (key paper requested): full text read; only an RNAi tool use of gpr-1/2 to
abolish pulling forces. LOW relevance, not a GOA source for gpr-2.
- Core: GoLoco GDI for GOA-1/GPA-16 (IDA x2: PMID:16162648, PMID:18984596; plus PMID:12814548),
in the cortical Galpha-GPR-1/2-LIN-5 force generator positioning the mitotic spindle.
- GO:0008277 regulation of GPCR signaling pathway: GPR-1/2 act receptor-independently
PMID:12814548;
marked over-annotated (same as gpr-1).
- No NEW terms. G-protein alpha-subunit binding (GO:0001965) is on gpr-1 by IPI but not gpr-2;
it is entailed functionally by the GDI activity and not added. Spindle orientation in
EMS/P2 rests on RNAi phenotype plus localization; left as a question.