Falcon deep research report for PFDN1
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
A human protein-protein interaction network: a resource for annotating the proteome.
Interaction of hepatitis C virus F protein with prefoldin 2 perturbs tubulin cytoskeleton organization.
A directed protein interaction network for investigating intracellular signal transduction.
Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates.
Architecture of the human interactome defines protein communities and disease networks.
The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.
A reference map of the human binary protein interactome.
The functions and mechanisms of prefoldin complex and prefoldin-subunits.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A comprehensive analysis of prefoldins and their implication in cancer.
Multimodal cell maps as a foundation for structural and functional genomics.
Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.
The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation
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Prefoldin complex physically associates with pVHL in human cells and prefoldin knockdown reduces pVHL expression
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In yeast, prefoldin mutants promote pVHL aggregation, supporting a role in client stabilization beyond actin and tubulin
DIP-MS ultra-deep interaction proteomics for the deconvolution of protein complexes
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DIP-MS resolved canonical and alternative prefoldin assemblies in human cells, with PFDN1 as a component, supporting modular complex isoforms
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Prefoldin subunits show coelution and association patterns linked to CCT/TRiC with n equals 3 biologically independent replicates
Prefoldin 1 promotes EMT and lung cancer progression by suppressing cyclin A expression
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PFDN1 increases during TGF-beta1-induced EMT and localizes to the nucleus in cancer contexts
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PFDN1 represses cyclin A expression by directly interacting with the cyclin A promoter near the transcription start site
PFDN1 an indicator for colorectal cancer prognosis enhances tumor cell proliferation and motility through cytoskeletal reorganization
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PFDN1 knockdown reduces F-actin levels and alpha-tubulin staining in colorectal cancer cells, consistent with impaired cytoskeletal homeostasis
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PFDN1 knockdown in xenografts reduced tumor weight to 346.8 mg versus 783.4 mg in controls (P less than 0.01)
Prefoldin function in cellular protein homeostasis and human diseases