Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II.
The human PAF complex coordinates transcription with events downstream of RNA synthesis.
Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.
Parafibromin inhibits cancer cell growth and causes G1 phase arrest.
BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling.
The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene.
Purification of proteins associated with specific genomic Loci.
The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors.
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.
The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.
The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis.
Transcriptional activators enhance polyadenylation of mRNA precursors.
A directed protein interaction network for investigating intracellular signal transduction.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.
Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling.
Architecture of the human interactome defines protein communities and disease networks.
PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Recruitment of elongation factors to form elongation complex
Addition of nucleotides leads to transcript elongation
Resumption of elongation after recovery from pausing
Abortive termination of elongation after arrest
Separation of elongating transcript from template
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing
Pol II elongation complex moves on the template as transcript elongates
TFIIS-mediated recovery of elongation from arrest
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest
Elongating transcript encounters a lesion in the template
Beta-catenin recruits CDC73 and LEO1
RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B
RNF20:RNF40 monoubiquitinates Histone H2B
CHD1:H3K4me3 interacts with post-initiation transcription complexes
The parafibromin tumor suppressor protein is part of a human Paf1 complex.
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
hCTR9, a component of Paf1 complex, participates in the transcription of interleukin 6-responsive genes through regulation of STAT3-DNA interactions.