Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

PMID:21233210

ARF-like protein 16 (ARL16) inhibits RIG-I by binding with its C-terminal domain in a GTP-dependent manner.

GTP-bound ARL16 binds the RIG-I CTD and inhibits RIG-I signalling.

"ARL16 interacted with the C-terminal domain (CTD) of RIG-I to suppress the association between RIG-I and RNA."

PMID:25416956

A proteome-scale map of the human interactome network.

PMID:31515488

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

PMID:32296183

A reference map of the human binary protein interactome.

PMID:32814053

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

PMID:35196065

Phylogenetic profiling and cellular analyses of ARL16 reveal roles in traffic of IFT140 and INPP5E.

ARL16 localizes along the ciliary axoneme in RPE1 cells.

"revealed that ARL16 localizes along the ciliary axoneme in a punctate manner (Figure 2A)."
Arl16 knockout blocks Golgi export of IFT140 and INPP5E.

"Instead, both INPP5E and IFT140 accumulate at the Golgi in Arl16 KO lines, while other intraflagellar transport (IFT) proteins do not, suggesting a specific defect in traffic from Golgi to cilia."

PMID:38606629

Mapping the global interactome of the ARF family reveals spatial organization in cellular signaling pathways.

ARL16 has an atypical G-3 motif.

"ARL16 was kept in its wild-type (WT) form as the G-3 motif is atypic"

file:human/ARL16/ARL16-uniprot.txt

UniProt entry Q0P5N6 (ARL16_HUMAN)

file:human/ARL16/ARL16-deep-research-affinage.md

Affinage mechanistic annotation for ARL16 (human)