SMIM36 notes

2026-10-03 - initial review (MICROPROTEINS Tier 2)

Identity

• UniProt A0A1B0GVT2 (SIM36_HUMAN), 93 aa, PE1 (proteomics identification). HGNC:53654, chr 17q22.
  No aliases in NCBI Gene (GeneID 101927367); gene previously known only by its LOC number.
• Single predicted helical TM segment near the N-terminus, residues 14-34
  [file:human/SMIM36/SMIM36-uniprot.txt "FT TRANSMEM 14..34"]; C-terminal disordered region 73-93
  [file:human/SMIM36/SMIM36-uniprot.txt "FT REGION 73..93"]. The C-terminal half is Pro/Gly-rich
  (own sequence inspection). Membrane location is by sequence prediction (ECO:0000255).
• Ensembl: ENSG00000261873, chr17:55449856-55511452 (- strand), ~62 kb locus; only unnamed lncRNAs overlap.

Family / conservation

• Own family: InterPro IPR063159 SMIM36, Pfam PF30955 [file:human/SMIM36/SMIM36-uniprot.txt "DR InterPro; IPR063159; SMIM36."]. No PANTHER family; PAN-GO 0 IBA.
• Ensembl Compara (REST homology/id/human/ENSG00000261873, orthologues): 89 species, including teleosts
  (danio_rerio, cyprinodon_variegatus) and reptiles/birds -> conserved across bony vertebrates. No human paralogues listed.

Expression

• HPA "Group enriched (retina, testis)" [file:human/SMIM36/SMIM36-uniprot.txt "DR HPA; ENSG00000261873; Group enriched (retina, testis)."]; Bgee top: testis.

Literature

• PubMed esearch "SMIM36" (2026-10-03): 1 hit, PMID:41153404 (psoriasis anti-IL-17 response GWAS, 88 patients).
  An intronic SNP of SMIM36 is among 21 response-associated variants
  PMID:41153404, but the authors' own functional reading assigns it
  to a neighbouring gene: PMID:41153404.
  Small cohort, needs replication; says nothing about the SMIM36 protein.
• NCBI Gene-linked PMIDs: only the chr17 genome sequencing paper (16625196).

Conclusion

• No functional literature. IEA membrane: ACCEPT. core_functions empty. No NEW terms. Not in gocams/index.tsv.
• Ensembl Compara spot check (2026-10-03): orthologues in rat, zebrafish, chimpanzee; NONE annotated in mouse
  (mus_musculus) - possible loss or annotation gap; relevant for choosing a model organism.