Gene Ontology annotation through association of InterPro records with GO terms.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods.
Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.
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CAPG reversibly blocks barbed ends of actin filaments
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CAPG does NOT sever preformed actin filaments
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Ca2+-sensitive activity
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Member of gelsolin/villin family
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Abundant in macrophages (0.9-1% of cytoplasmic protein)
A new role for nuclear transport factor 2 and Ran: nuclear import of CapG.
The F-actin filament capping protein CapG is a bona fide nucleolar protein.
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CAPG localizes to nucleolus
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ATP-dependent nucleolar transport
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Requires active RNA Pol I transcription
Large-scale proteomics and phosphoproteomics of urinary exosomes.
The actin-capping protein CapG localizes to microtubule-dependent organelles during the cell cycle.
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CAPG at mother centriole in interphase
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CAPG at mitotic spindle in mitosis
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CAPG at midbody ring in abscission
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NUP62 colocalizes with CAPG at midbody
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
A proteome-scale map of the human interactome network.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
GOA annotation export for CAPG
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GOA records the phylogenetic IBA source for the CAPG GO:0051014 annotation.
"UniProtKB P40121 CAPG involved_in GO:0051014 actin filament severing biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:95851|PANTHER:PTN000240164|UniProtKB:P06396|UniProtKB:P09327|UniProtKB:Q28046|UniProtKB:Q9Y6U3|WB:WBGene00010593 9606 Homo sapiens GO_Central Macrophage-capping protein 20231108"
Deep research on CAPG function
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CAPG is barbed-end capping protein (not severing)
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Regulated by Ca2+ and PIP2
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Redox-sensitive via C282/C290
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Nucleo-cytoplasmic shuttling
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Overexpressed in cancers
OpenScientist hypothesis report for CAPG GO:0051014