Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2
The complete original comment and source metadata are preserved in predictions source. There are no GO-term predictions for this record. The phmmer donor is fission-yeast Esf2 O74362, score 77.1.
SSU-processome assembly/function and 18S-rRNA synthesis: CNN. These broad claims are supported by the specific ABT1/Esf2 family assignment and direct experimental characterization of budding-yeast Esf2 in PMID:15964808(https://pubmed.ncbi.nlm.nih.gov/15964808/). “Esf2p-depleted cells are defective for pre-rRNA processing at the early nucleolar cleavage sites A0 through A2 and consequently are inhibited for 18S rRNA synthesis.” These conserved functions are already represented by the existing fly IBA annotations. Transfer is justified by the specific family, retained RNA-binding region and conserved ribosome-assembly mechanism.
Requirement for the specifically named sites A0, A1 and A2: UNC. These are the experimentally characterized yeast processing sites. The available evidence does not independently map those precise sites in Drosophila or demonstrate that CG32706 is required at each. Conserved participation in early maturation does not validate that exact statement; it remains unresolved, and does not imply intrinsic nuclease activity. O74362 repeats a by-similarity paragraph and is not independent experimental validation. The target’s precise biochemical contacts remain inferred.