Gene Ontology annotation through association of InterPro records with GO terms
Sequence similarity evidence used in manual assertion
Use of the ND evidence code for Gene Ontology (GO) terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome.
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First identification of BBS8/TTC8; showed BBS proteins localize to basal bodies and centrosomes
"BBS8 localizes specifically to ciliated structures, such as the connecting cilium of the retina and columnar epithelial cells in the lung"
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All C. elegans BBS homologues are expressed exclusively in ciliated neurons
"all available Caenorhabditis elegans BBS homologues are expressed exclusively in ciliated neurons"
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BBS8 contains regulatory elements for RFX transcription factor, which modulates ciliogenesis genes
"contain regulatory elements for RFX, a transcription factor that modulates the expression of genes associated with ciliogenesis and intraflagellar transport"
Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.
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bbs-7 and bbs-8 mutations cause structural and functional defects in cilia
"mutations in the Caenorhabditis elegans bbs-7 and bbs-8 genes cause structural and functional defects in cilia"
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BBS proteins localize predominantly at the base of cilia
"C. elegans BBS proteins localize predominantly at the base of cilia"
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BBS proteins move bidirectionally along the ciliary axoneme like IFT proteins
"like proteins involved in intraflagellar transport (IFT), a process necessary for cilia biogenesis and maintenance, move bidirectionally along the ciliary axoneme"
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BBS-7 and BBS-8 are required for normal localization/motility of IFT proteins OSM-5 and CHE-11
"BBS-7 and BBS-8 are required for the normal localization/motility of the IFT proteins OSM-5/Polaris and CHE-11"
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bbs mutants may exhibit sensory defects leading to behavioral abnormalities
"some of the cardinal and secondary symptoms of BBS, such as obesity, diabetes, cardiomyopathy, and learning defects may result from cilia dysfunction"
Caenorhabditis elegans integrates the signals of butanone and food to enhance chemotaxis to butanone.
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BBS genes are required in AWC(ON) neuron for butanone enhancement (olfactory learning)
"Butanone enhancement also required the functions of Bardet-Biedl syndrome genes in the AWC(ON) neuron but not other genes that control ciliary transport"
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BBS gene function in sensory cilia is important for this learning behavior
"the functions of Bardet-Biedl syndrome genes in sensory cilia may play an important role in this plasticity"
The BBSome controls IFT assembly and turnaround in cilia.
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The BBSome assembles IFT complexes at the ciliary base
"Further analyses revealed that the BBSome (refs 3, 4), a group of conserved proteins affected in human Bardet-Biedl syndrome(5) (BBS), assembles IFT complexes at the ciliary base"
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The BBSome binds to anterograde IFT particles and reaches the ciliary tip
"assembles IFT complexes at the ciliary base, then binds to the anterograde IFT particle in a DYF-2- (an orthologue of human WDR19) and BBS-1-dependent manner, and lastly reaches the ciliary tip to regulate proper IFT recycling"
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The BBSome regulates proper IFT recycling/turnaround at the ciliary tip
"lastly reaches the ciliary tip to regulate proper IFT recycling"
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In bbs-7 and bbs-8 null worms, IFT-A and IFT-B dissociate during anterograde transport
"In bbs-7 and bbs-8 null worms, IFT-A and IFT-B dissociate in anterograde IFT transport, resulting in IFT-A moving alone with kinesin-II and IFT-B moving alone with OSM-3"
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The BBSome is required for assembling IFT particles
"Taken together, we conclude that the BBSome is required for assembling IFT particles at both ciliary base and tip"
Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron.
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BBS-8 localizes at the ciliary base in AFD neurons
"One compartment, a bona fide cilium, is delineated by proteins associated with Bardet-Biedl syndrome (BBS), Meckel syndrome and nephronophthisis at its base"
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BBS-8 is required for correct localization of guanylyl cyclases in AFD neurons
"requires BBS-8 and DAF-25 (known as Ankmy2 in mammals) for correct localization of guanylyl cyclases needed for thermosensation"
Whole-organism developmental expression profiling identifies RAB-28 as a novel ciliary GTPase associated with the BBSome and intraflagellar transport.
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RAB-28 association with the periciliary membrane and IFT is BBS-8 dependent
"RAB-28 association with the periciliary membrane and IFT is dependent on GTP-binding and the BBSome subunit orthologue, BBS-8"
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bbs-8 mutants show impaired localization of activated RAB-28 to the periciliary membrane
"BBSome-dependent recruitment of activated RAB-28 to the periciliary membrane"
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BBS-8 facilitates cargo targeting to ciliary membranes
"RAB-28 association with the periciliary membrane and IFT is dependent on GTP-binding and the BBSome subunit orthologue, BBS-8"
Deep research report on bbs-8