Deep research on ITIH2 gene function and biology
Falcon (Edison Scientific Literature) deep research on ITIH2 — synthesizes 2024 reviews on the inter-alpha-trypsin inhibitor heavy chain H2, including the TSG-6-catalyzed covalent transesterification of HC2 onto hyaluronan, the resulting HC·HA (SHAP-HA) structural complexes that stabilize HA-rich extracellular matrix, proteolytic editing of HC·HA by ADAMTS5/MMP7, and disease associations (tumor suppression in solid cancers, follicular fluid biomarkers for embryo quality, late-onset preeclampsia)
Gene Ontology annotation through association of InterPro records with GO terms.
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Combined Automated Annotation using Multiple IEA Methods.
The human plasma proteome: a nonredundant list developed by combination of four separate sources.
TSG-6 potentiates the antitissue kallikrein activity of inter-alpha-inhibitor through bikunin release.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
The TSG-6/HC2-mediated transfer is a dynamic process shuffling heavy chains between glycosaminoglycans.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan.
A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor.
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Hyaluronic Acid Interacting Molecules Mediated Crosstalk between Cancer Cells and Microenvironment from Primary Tumour to Distant Metastasis.
The function of the inter-alpha-trypsin inhibitors in the development of disease.
FAM20C phosphorylates FAM20C substrates