Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB keywords
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L).
The Polycomb-associated protein Rybp is a ubiquitin binding protein.
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.
Imbalances in p97 co-factor interactions in human proteinopathy.
Proteomic characterization of the human sperm nucleus.
Hierarchical binding of cofactors to the AAA ATPase p97.
Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK).
A non-canonical role of the p97 complex in RIG-I antiviral signaling.
The AAA+ ATPase p97, a cellular multitool.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
The p97-UBXN1 complex regulates aggresome formation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Ribosome-associated quality-control mechanisms from bacteria to humans.
Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis.
Study of Clinical Characteristics of Intellectual Disability in Morocco.
Reactome: nucleoplasm localization (signaling-related pathway)
Reactome: nucleoplasm localization (signaling-related pathway)
Reactome: KEAP1-NFE2L2 / cytosol localization
Reactome: cytosol localization
Reactome: cytosol localization
Reactome: cytosol localization
OpenScientist hypothesis run: NPLOC4 pseudo-DUB MPN catalytic check
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Confirms NPL4's MPN domain is a catalytically inactive pseudo-DUB - it lacks the JAMM/MPN+ zinc-metalloprotease motif and adversarial checks rule out all six DUB mechanistic families - so deubiquitinase activity (GO:0004843) is correctly absent and should not be annotated (the term is also mechanistically wrong, as MPN DUBs are zinc metalloproteases, not cysteine-type proteases).
"NPLOC4 has no deubiquitinase activity of any type"