Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on inter-ontology links
Novel salivary antihemostatic activities of long-form D7 proteins from the malaria vector Anopheles gambiae facilitate hematophagy
-
D7L2 weakly binds leukotrienes B4 and D4
"AngaD7L2 weakly binds leukotrienes B4 and D4"
-
D7L2 has anticoagulant activity targeting the intrinsic pathway
"AngaD7L2 had a dose-dependent anticoagulant effect via the intrinsic coagulation pathway"
-
D7L2 binds coagulation factors XII, XIIa, and XI
"B, kinetic analysis of AngaD7 with FXII (B), FXIIa (C), and FXI (D)"
-
D7L2 inhibits generation of factors XIIa and XIa
"AngaD7L2 inhibits generation of FXIIa and FXIa in normal plasma"
UniProt entry for D7L2_ANOGA
-
D7L2 modulates blood feeding by binding host mediators
"Modulates blood feeding of female mosquitoes on vertebrate species by binding and sequestering different mediators involved in the host response"
-
D7L2 binds leukotrienes B4 and D4
"Binds leukotriene B4 and leukotriene D4"
-
D7L2 has anticoagulant activity targeting intrinsic pathway
"Exhibits anticoagulant activity targeting the intrinsic coagulation pathway; binds coagulation factors XII and XI, preventing generation of activated FXIIa and FXIa"
-
D7L2 interacts with host coagulation factor XII
"Interacts with host coagulation factor XII/F12 (inactive and activated) (PubMed:35460690)"
-
D7L2 interacts with host coagulation factor XI
"Interacts with host coagulation factor XI/F11 (inactive) (PubMed:35460690)"
-
Protein is secreted
"SUBCELLULAR LOCATION: Secreted"
Deep research review of D7 protein family function and evolution
-
D7 proteins function as kratagonists that scavenge host signaling molecules
"D7 proteins are among the most abundant mosquito salivary proteins and function as kratagonists - high-affinity scavengers of host small-molecule inflammatory and hemostatic mediators"
-
Long-form D7s bind lipid mediators including leukotrienes
"long-form D7s bind lipid mediators (cysteinyl leukotrienes; some bind thromboxane A2 analogs) via their N-terminal domain"
-
D7 proteins are secreted in saliva during feeding
"D7r1 is produced in adult female salivary glands and secreted in saliva at the skin interface during probing/feeding"