Gene Ontology annotation through association of InterPro records with GO terms.
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Automatic assignment of GO terms using logical inference, based on inter-ontology links.
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.
A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily.
Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
A role for phospholipase D3 in myotube formation.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.
Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing.
Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes.
PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing.
PLD3 and spinocerebellar ataxia.
A reference map of the human binary protein interactome.
Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism.
PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes.
Deep research summary for PLD3
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PLD3 is a type II transmembrane protein that traffics to lysosomes where it functions as a 5'-3' exonuclease
"PLD3 encodes phospholipase D3, a type II single-pass transmembrane glycoprotein localized to the endolysosomal system in human cells"
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PLD3 also synthesizes BMP lipids essential for lysosomal lipid catabolism
"A 2024 Cell study reports purified PLD3 (and paralog PLD4) synthesize the S,S stereoisomer of bis(monoacylglycero)phosphate (S,S-BMP) via a transphosphatidylation reaction in lysosomal contexts"
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PLD3 loss leads to accumulation of nucleic acids and activation of innate immune signaling
"In PLD3 deficiency, luminal nucleic acids accumulate and can chronically activate TLRs; leakage of mtDNA into cytosol activates cGAS-STING signaling"
Cyberian deep research on PLD3 function