Gene Ontology annotation through association of InterPro records with GO terms

InterPro domain mappings support conserved molecular features but can over-project broad DNA/lipid/dimerization functions without Arabidopsis-specific evidence.

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

UniProt subcellular-location mappings provide conservative localization support when consistent with transcription-factor biology.

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Logical inference supplies broad transcriptional-regulation process annotations from molecular function terms; these should often be narrowed to the gene-specific regulatory context.

GO_REF:0000122

AtSubP analysis

AtSubP prediction supports localization hypotheses but is weaker than direct localization experiments.

PMID:11041882

The TT8 gene encodes a basic helix-loop-helix domain protein required for expression of DFR and BAN genes in Arabidopsis siliques.

TT8 encodes a bHLH protein required for DFR and BAN expression in Arabidopsis siliques.

PMID:11118137

Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.

PMID:12679534

The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.

PMID:15255866

TT2, TT8, and TTG1 synergistically specify the expression of BANYULS and proanthocyanidin biosynthesis in Arabidopsis thaliana.

TT2, TT8, and TTG1 synergistically specify BANYULS expression and proanthocyanidin biosynthesis.

PMID:15361138

Comprehensive identification of Arabidopsis thaliana MYB transcription factors interacting with R/B-like BHLH proteins.

TT8 and related bHLH proteins interact with MYB partners in flavonoid regulatory complexes.

PMID:16709193

TT8 controls its own expression in a feedback regulation involving TTG1 and homologous MYB and bHLH factors, allowing a strong and cell-specific accumulation of flavonoids in Arabidopsis thaliana.

TT8 participates in feedback regulation with TTG1 and MYB/bHLH factors enabling cell-specific flavonoid accumulation.

PMID:18532977

AtMYBL2, a protein with a single MYB domain, acts as a negative regulator of anthocyanin biosynthesis in Arabidopsis.

AtMYBL2 acts as a negative regulator of anthocyanin biosynthesis through interactions with MBW components.

PMID:18784284

Functional specialization of the TRANSPARENT TESTA GLABRA1 network allows differential hormonal control of laminal and marginal trichome initiation in Arabidopsis rosette leaves.

TT8 contributes to differential hormonal control of laminal and marginal trichome initiation, a context-specific MBW output.

PMID:21551388

The Jasmonate-ZIM-domain proteins interact with the WD-Repeat/bHLH/MYB complexes to regulate Jasmonate-mediated anthocyanin accumulation and trichome initiation in Arabidopsis thaliana.

JAZ proteins modulate WD-repeat/bHLH/MYB complexes affecting jasmonate-mediated anthocyanin and trichome outputs.

PMID:24722549

TRANSPARENT TESTA8 Inhibits Seed Fatty Acid Accumulation by Targeting Several Seed Development Regulators in Arabidopsis.

TT8 binds regulatory regions and affects seed-development regulators and seed fatty-acid accumulation.

PMID:28650476

CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping.

file:ARATH/TT8/TT8-deep-research-falcon.md

Falcon deep research for Arabidopsis TT8

TT8 is the bHLH component of MYB-bHLH-WD40 transcriptional activation complexes controlling seed proanthocyanidin and anthocyanin/flavonoid genes.
The major seed MBW complex TT2-TT8-TTG1 activates direct targets including DFR, LDOX/ANS, BAN/ANR, TT12, TT19, and AHA10.

file:ARATH/TT8/TT8-uniprot.txt

UniProt record for Arabidopsis TT8

UniProt identifies TT8/Q9FT81 as a bHLH transcription activator that controls flavonoid pigmentation and regulates BANYULS and DFR expression.

file:interpro/panther/PTHR46266/PTHR46266-entries.csv

PANTHER PTHR46266 family entries for Arabidopsis TT8

PTHR46266 places TT8 and GL3 in plant-specific bHLH transcription activators; TT8 subfamily assignment supports conserved bHLH transcription factor and dimerization functions, while seed flavonoid specificity comes from Arabidopsis evidence.