Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Towards a proteome-scale map of the human protein-protein interaction network.
Shifted Transversal Design smart-pooling for high coverage interactome mapping.
Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels.
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KCNRG reduces K+ currents through hKv1.1 and hKv1.4 when co-expressed in Xenopus oocytes.
"The K(+) channel regulator protein (KCNRG), identified as a putative tumor suppressor, reduces K(+) currents through human K(+) channels hKv1.1 and hKv1.4 expressed in Xenopus oocytes."
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Current attenuation requires the N-terminal T1 domain of KCNRG.
"Current attenuation requires the presence of the N-terminal T1 Domain"
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Immunoprecipitation shows KCNRG associates with the N-terminus of Kv channels.
"immunoprecipitation experiments suggest association of KCNRG with the N-terminus of the channel"
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KCNRG is an ER-associated protein.
"Our data indicates that KCNRG is an ER-associated protein"
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KCNRG regulates Kv1 channels by retaining a fraction in endomembranes.
"we propose regulates Kv1 family channel proteins by retaining a fraction of channels in endomembranes"
A proteome-scale map of the human interactome network.
A reference map of the human binary protein interactome.
A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3.
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Original identification of KCNRG as potassium channel regulator.
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Located in 13q14.3 region frequently deleted in B-cell malignancies.
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Inhibits potassium fluxes in cells.
Deep research report on KCNRG
Cyberian deep research on KCNRG function