OpenScientist focused review — STAT3 positive regulation of cell migration (GO:0030335) core vs downstream
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Verdict NON-CORE — migration is a real but downstream transcriptional consequence of STAT3's core transcription factor activity, not migration machinery; retain the annotation but reclassify as non-core (resolve UNDECIDED to non-core).
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STAT3 drives migration mainly by transcriptionally inducing pro-migratory targets (Twist1, MMP-1/2/3/9/10/13); bidirectional context-dependent effects (it also carries GO:2001223 negative regulation of neuron migration) are the hallmark of a TF.
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A genuine non-transcriptional STAT3-stathmin (STMN1) microtubule-stabilizing mechanism exists (PMID:16401721, PMID:19251695) but is context-limited and has no GO cytoskeletal annotation — a possible evidence/annotation gap for expert review.
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Citation verification (PubMed) confirmed all pivotal PMIDs are real; it also found the supporting reference PMID:31638206 is indexed as a RETRACTED publication — a curation-relevant caveat the agent report did not flag.
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300.
Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family.
Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.
Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin.
The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine.
Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component.
MEN2A-RET-induced cellular transformation by activation of STAT3.
Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway.
ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner.
PTP1B regulates leptin signal transduction in vivo.
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation.
Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling.
Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2.
STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling.
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3.
Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif.
Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene.
Stat3 dimerization regulated by reversible acetylation of a single lysine residue.
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.
Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway.
STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation.
Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling.
Mechanisms of type-I- and type-II-interferon-mediated signalling.
JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3.
A quantitative protein interaction network for the ErbB receptors using protein microarrays.
STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen.
Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter.
Physical and functional interactions between Daxx and STAT3.
Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA.
Tid1 isoforms are mitochondrial DnaJ-like chaperones with unique carboxyl termini that determine cytosolic fate.
Identification of STAT3 as a specific substrate of breast tumor kinase.
Interleukin-6 induces hepcidin expression through STAT3.
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation.
Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells.
leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3.
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.
Crif1 is a novel transcriptional coactivator of STAT3.
BART is essential for nuclear retention of STAT3.
Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection.
The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain.
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors.
ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells.
Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway.
Hsp105beta upregulates hsp70 gene expression through signal transducer and activator of transcription-3.
STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress.
Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.
The role of the c-Jun N-terminal kinase 2-α-isoform in non-small cell lung carcinoma tumorigenesis.
Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3.
Epigenetic regulation of CpG promoter methylation in invasive prostate cancer cells.
Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer.
Next-generation sequencing to generate interactome datasets.
The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways.
A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40.
Toward an understanding of the protein interaction network of the human liver.
The Sin3a repressor complex is a master regulator of STAT transcriptional activity.
CCR1-mediated STAT3 tyrosine phosphorylation and CXCL8 expression in THP-1 macrophage-like cells involve pertussis toxin-insensitive Gα(14/16) signaling and IL-6 release.
ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling.
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells.
STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells.
STAT heterodimers in immunity: A mixed message or a unique signal?
EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.
A small GTPase‑like protein fragment of Mycoplasma promotes tumor cell migration and proliferation in vitro via interaction with Rac1 and Stat3.
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.
Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice.
SH2B1β interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation.
Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis.
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
The STAT3-binding long noncoding RNA lnc-DC controls human dendritic cell differentiation.
β1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway.
Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling.
A proteome-scale map of the human interactome network.
A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.
Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity.
miR-874 functions as a tumor suppressor by inhibiting angiogenesis through STAT3/VEGF-A pathway in gastric cancer.
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
Phospho-tyrosine dependent protein-protein interaction network.
IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways.
PIPINO: A Software Package to Facilitate the Identification of Protein-Protein Interactions from Affinity Purification Mass Spectrometry Data.
Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice.
Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes.
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T(H)17 cells.
Novel Resolvin D2 Receptor Axis in Infectious Inflammation.
Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation.
Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.
PPARγ Links BMP2 and TGFβ1 Pathways in Vascular Smooth Muscle Cells, Regulating Cell Proliferation and Glucose Metabolism.
IL-11 induces differentiation of myeloid-derived suppressor cells through activation of STAT3 signalling pathway.
A double helical motif in OCIAD2 is essential for its localization, interactions and STAT3 activation.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca(2+) fluxes and apoptotic responses.
ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells.
Physical proximity and functional cooperation of glycoprotein 130 and glycoprotein VI in platelet membrane lipid rafts.
Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
MicroRNA‑4500 suppresses tumor progression in non‑small cell lung cancer by regulating STAT3.
miR-98 Modulates Cytokine Production from Human PBMCs in Systemic Lupus Erythematosus by Targeting IL-6 mRNA.
Prohibitin 1 interacts with signal transducer and activator of transcription 3 in T-helper 17 cells.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
Biochanin A impedes STAT3 activation by upregulating p38δ MAPK phosphorylation in IL-6-stimulated macrophages.
A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Human transcription factor protein interaction networks.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
A novel gain-of-function STAT3 variant in infantile-onset diabetes associated with multiorgan autoimmunity.
Integrin αVβ1-activated PYK2 promotes the progression of non-small-cell lung cancer via the STAT3-VGF axis.
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions.
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes.
IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes.
Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.
Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction.
Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.
Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation.
STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription.
A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9.
Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis.
The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor.
Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony-stimulating factor receptor.
Phosphorylated STAT1, STAT3 form dimers
Tyrosine phosphorylated IL6ST binds STAT1,STAT3
STAT1 and STAT3 dimers translocate to the nucleus
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
Phosphorylated STATs are released
Serine phosphorylation of STATs
Disassociation and translocation of STATs to the nucleus
FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3
POU5F1 (OCT4), STAT3 bind the SALL4 promoter
STAT binds to the active receptor
STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3
p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm
p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3
p-Y705-STAT3,p-Y641-STAT6 dissociate
JAK1 phosphorylates STAT3,STAT6
p-Y705-STAT3, p-Y641-STAT6 dimerise
STAT3,STAT6 bind p-Y-IL4R
p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus
STAT1,STAT3,STAT6 bind IL13:IL13R type II
STAT1,STAT3,STAT6 phosphorylation
p-Y-STATs translocate to nucleus
STAP2 recruits STAT3 to PTK6
PTK6 phosphorylates STAT3
STAT3 binds SOCS3 promoter
STAT3 binds activated MET receptor
STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus
p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus
p-Y705-STAT3 binds p-Y693-STAT4
STAT4 binds p-Y-IL23R in IL23:IL23 receptor
p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB
IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3
IL19:IL20RA:p‑JAK1:IL20RB binds STAT3
STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex
p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5
p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5
p-Y-STAT3:p-STAT5 translocates to the nucleus
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3
IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B
p-Y701-STAT1 binds p-Y705-STAT3
p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus
IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5
IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5
p-STAT3 dimer translocates from cytosol to nucleoplasm
IL24:IL22RA1:p-JAK1:IL20RB binds STAT3
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3
IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3
IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3
IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3
p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3
p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1
p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3
IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5
p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3
IL21 receptor STAT phosphorylation
IL21 receptor STAT binding
Phosphorylation of STATs downstream of KIT mutants
Recruitment of STATs by KIT mutants
Dimerization of STATs downstream of KIT mutants
Disassociation and translocation of STATs to the nucleus downstream of KIT mutants
STAT binds to p-11Y PDGFRA extracellular domain dimers
STAT binds to the mutant PDGFRA receptor
STAT3 is phosphorylated downstream of active ALK
p-Y705,S727-STAT3 dimerizes
p-Y705, p-S727 STAT3 dimer translocates to the nucleus
p-Y705,S727 STAT3 is acetylated
p-Y705, S727 STAT3 dimer binds HIF1A gene
p-Y705, S727 STAT3 dimer binds CD274 gene
AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter
AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter
HDACs deacetylate p-STAT3 dimers
ALK mutants phosphorylate STAT3
pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants
AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene
AcK685 pY705,S727 STAT3 binds the MIR21 gene
AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter
STAT3, DNMT1 and HDAC1 bind PTPN6 gene
p-Y705, S727 STAT3 dimer binds ICOS promoter
pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK
p-Y705,S727 STAT3 dimer binds NOTCH gene
TYK2-dependent STAT1 and STAT3 phosphorylation
Deep research report on STAT3