Use of the ND evidence code for Gene Ontology (GO) terms
Combined Automated Annotation using Multiple IEA Methods
UniProtKB entry for MTC7_YEAST
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Mtc7 is a small predicted multi-pass membrane protein with two transmembrane helices and no established molecular function.
"FUNCTION: May be involved in telomere capping. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TRANSMEM features are annotated at residues 13-33 and 42-62."
A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae
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MTC7 was named as a maintenance-of-telomere-capping gene from a genome-wide cdc13-1 genetic interaction screen.
"We also identified a number of genes of previously unknown function that we term RTC, for restriction of telomere capping, or MTC, for maintenance of telomere capping."
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The evidence is genetic and phenotypic rather than a direct molecular demonstration of Mtc7 function at telomeres.
"We identified 369 gene deletions, in eight different phenotypic classes, that reproducibly demonstrated subtle genetic interactions with the cdc13-1 mutation."
Falcon deep research report for MTC7
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Falcon found limited direct mechanistic literature for MTC7 and supports a cautious telomere-capping-related process annotation.
"MTC7 is a poorly characterized gene with limited direct mechanistic literature; current interpretation relies on genetic association plus modern telomere-capping context rather than a definitive molecular mechanism."