STM review notes
Review scope: Arabidopsis thaliana STM / SHOOT MERISTEMLESS, UniProt Q38874,
At1g62360. Files reviewed: STM-ai-review.yaml, STM-goa.tsv,
STM-uniprot.txt, STM-deep-research-falcon.md, local cached publications
referenced by GOA, and PANTHER family context PTHR11850.
Key synthesis:
- STM is a class I KNOX/TALE homeobox transcription factor. UniProt states it is
required for shoot apical meristem formation and probably binds the DNA
sequence 5'-TGAC-3' [file:ARATH/STM/STM-uniprot.txt "Required for shoot
apical meristem (SAM) formation during embryogenesis"; "Probably binds to the
DNA sequence 5'-TGAC-3'"].
- STM suppresses differentiation and promotes cell division in the meristem
independently of WUS PMID:12070094.
- STM contributes to CLV3/stem-cell homeostasis with WUS at later developmental
stages PMID:12068101.
- STM/KNOXI activity activates cytokinin biosynthesis, including AtIPT7 induction
and increased cytokinin levels PMID:16139212.
- STM nuclear localization depends on BLH/BELL partner heterodimerization
PMID:16513846.
- STM trafficking is regulated by FTIP3/FTIP4 and is tied to nuclear recycling,
plasma membrane localization, and intercellular trafficking [PMID:29742441
"This facilitates STM recycling to the nucleus"; "STM localizes substantially
to the plasma membrane, which promotes intercellular trafficking"].
- Generic
protein binding rows were not treated as core functions. Targeted
KNOX-BELL interaction evidence was modified to protein heterodimerization
activity; high-throughput generic interaction rows were removed or marked
over-annotated where they did not add mechanistic STM evidence.
- The RNA-binding GOA row was removed. The accessible PMID:17965274 text supports
MPB2C as an RNA and HD motif binding protein, and UniProt describes STM RNA
binding as "By similarity", not direct Arabidopsis STM evidence.