Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3.
Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.
The autophagy machinery is required to initiate hepatitis C virus replication.
Network organization of the human autophagy system.
A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate.
Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy.
Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12.
WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.
A proteome-scale map of the human interactome network.
Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners.
Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay.
A reference map of the human binary protein interactome.
RAB33B recruits the ATG16L1 complex to the phagophore via a noncanonical RAB binding protein.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy.
LC3 binds the autophagosome membrane Atg5-Atg12 complex
ATG16L1 complex transfers LC3 from ATG3 to PE
WIPI2 binds ATG12:ATG5:ATG16L
ATG10 dissociates from ATG12:ATG5
ATG10 transfers ATG12 from ATG10 to ATG5
LC3 binds the autophagosome membrane Atg5-Atg12 complex
ATG12 forms a thioester bond with ATG7 dimer
The Atg5 Atg12 conjugate associates with innate antiviral immune responses.
ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death.
The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis.
Activation of antibacterial autophagy by NADPH oxidases.
Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy.
Piecemeal microautophagy of the nucleus requires the core macroautophagy genes.