Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae.
Global analysis of protein localization in budding yeast.
Mmm2p, a mitochondrial outer membrane protein required for yeast mitochondrial shape and maintenance of mtDNA nucleoids.
Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins.
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
An ER-mitochondria tethering complex revealed by a synthetic biology screen.
Composition and topology of the endoplasmic reticulum-mitochondria encounter structure.
Doa1 targets ubiquitinated substrates for mitochondria-associated degradation.
Complementation Assay Using Fusion of Split-GFP and TurboID (CsFiND) Enables Simultaneous Visualization and Proximity Labeling of Organelle Contact Sites in Yeast.
Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly.
A phospholipid transfer function of ER-mitochondria encounter structure revealed in vitro.
Structure-function insights into direct lipid transfer between membranes by Mmm1-Mdm12 of ERMES.
METALIC reveals interorganelle lipid flux in live cells by enzymatic mass tagging.
In situ architecture of the ER-mitochondria encounter structure.
Shared structural features of Miro binding control mitochondrial homeostasis.
Comparative analysis of mitochondrial proteomes across the tree of life.
-
Comparative proteomic/phylogenetic inference that Saccharomyces mitochondria retained the ERMES complex from the last opisthokont common ancestor, whereas human mitochondria lost it.
"the endoplasmic reticulum (ER)-mitochondria encounter structure (ERMES) complex from LOCA mitochondria, but human mitochondria lost these pathways"
Falcon deep research report for MDM34
ER-mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13.
-
Dominant VPS13 alleles suppress ERMES mutant mtDNA defects, so these defects are secondary.
"The fact that it suppresses ERMES mtDNA defects indicates that these are secondary to the loss of a primary ERMES function."
Peroxisomes are juxtaposed to strategic sites on mitochondria.
-
Peroxisomes localize to mitochondria-ER junctions and to sites of acetyl-CoA synthesis on mitochondria.
"peroxisomes are not randomly distributed in cells but are rather localized to specific mitochondrial subdomains such as mitochondria-ER junctions and sites of acetyl-CoA synthesis."
SGD gene description for MDM34 (yeast)