Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors.
Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5.
A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase.
Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases.
Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2.
Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength.
C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB).
Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase.
The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression.
An inhibitor of p38 MAP kinase downregulates cytokine release induced by sulfur mustard exposure in human epidermal keratinocytes.
Towards a proteome-scale map of the human protein-protein interaction network.
p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer.
Mxi2 promotes stimulus-independent ERK nuclear translocation.
A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis.
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.
Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase.
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs.
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor.
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis.
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.
A human MAP kinase interactome.
LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).
Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways.
Toward an understanding of the protein interaction network of the human liver.
HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms.
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
Protein arginine methyltransferase 1 interacts with and activates p38α to facilitate erythroid differentiation.
Metal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphatase.
The protein interaction landscape of the human CMGC kinase group.
SASH1 is a scaffold molecule in endothelial TLR4 signaling.
TNFα induces the expression of genes associated with endothelial dysfunction through p38MAPK-mediated down-regulation of miR-149.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Expression of Beta-Defensin 131 Promotes an Innate Immune Response in Human Prostate Epithelial Cells.
Regulation of Hippo signalling by p38 signalling.
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
MicroRNA-143-3p promotes human cardiac fibrosis via targeting sprouty3 after myocardial infarction.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.
Multimodal cell maps as a foundation for structural and functional genomics.
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine.
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.
Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases.
RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK).
Phosphorylated MAPKs phosphorylate ATF-2
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3
p38MAPK phosphorylates MSK1
p-MAPKAPK3 phosphorylates BMI1
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5
MAPKAPK5 phosphorylates TP53
Active p38 MAPK phosphorylates MAPKAPK5
ADP signalling through P2Y purinoceptor 1
P2Y purinoceptor 1 activates MAP kinase p38 alpha
Phosphorylation of cPLA2 by MAPK p38 alpha
Fgr may phosphorylate p38 MAPK
Phosphorylation of MEF2 proteins by p38
Nuclear translocation of p38 MAPK
Active p38 MAPK phosphorylates MAPKAPK2 or 3
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3
activated TAK1 mediates p38 MAPK activation
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
p38 MAPK activation by VEGFR
Exocytosis of secretory granule lumen proteins
Exocytosis of ficolin-rich granule lumen proteins
MAPK11 or MAPK14 phosphorylates NCF1 at Ser345
PLK2, MAPK14 phosphorylate ADAM17
CD163 mediating an anti-inflammatory response
USF1 is phosphorylated by p-MAPK14
Phosphorylation of CDC25A by p38 MAPK
UniProt entry Q16539 (MAPK14)
Falcon deep research report on MAPK14