Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.

Towards a proteome-scale map of the human protein-protein interaction network.

APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex.

Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.

Large-scale proteomics and phosphoproteomics of urinary exosomes.

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.

Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells.

Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment.

Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase.

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

A Y2H-seq approach defines the human protein methyltransferase interactome.

The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle.

Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway.

A proteome-scale map of the human interactome network.

Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages.

Phospho-tyrosine dependent protein-protein interaction network.

Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts.

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain.

Distinct Roles for APPL1 and APPL2 in Regulating Toll-like Receptor 4 Signaling in Macrophages.

Architecture of the human interactome defines protein communities and disease networks.

Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor.

Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

A reference map of the human binary protein interactome.

APPL2 Negatively Regulates Olfactory Functions by Switching Fate Commitments of Neural Stem Cells in Adult Olfactory Bulb via Interaction with Notch1 Signaling.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

OpenCell: Endogenous tagging for the cartography of human cellular organization.

APPL2 (Q8NEU8) sequence checks: orthology, paralogy and residue-level verification

UniProtKB record Q8NEU8 (DP13B_HUMAN), DCC-interacting protein 13-beta