TSC13 (YDL015C; UniProt Q99190) notes

Evidence journal (no paid deep research run; built from UniProt and cached publications).

Function

• Very-long-chain enoyl-CoA reductase (TECR orthologue; steroid 5-alpha reductase family), EC 1.3.1.93; essential, single copy [UniProt:Q99190].
• PMID:11113186.
• PMID:11113186.
• PMID:11113186.
• Reconstitution with two reductases PMID:17719544.

Location

• ER membrane, enriched at nucleus-vacuole junctions PMID:15958487; Nvj1-dependent; role in PMN vesicle size.
• Mitochondrial proteomics hits (Sickmann 2003, Reinders 2006) kept non-core.

Curation decisions

• protein binding (IPI with human ELOVL1, PMID:20937905) removed as uninformative.
• Oxidoreductase / CH-CH oxidoreductase / trans-2-enoyl-CoA reductase (NADPH, EC 1.3.1.38) -> MODIFY to GO:0102758.
• Cytosol RCA removed. Possible NEW location: nucleus-vacuole junction (not added; left as question).