Exact emitted record, retrieved 2026-09-10T14:34:34.331285+00:00.
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity
NPI (CS 0). The compound claim requires an autonomous G-protein-coupled receptor, whereas the exact input lacks the seven-transmembrane signaling module. The extracellular class C fold also does not establish glutamate specificity or inhibition of adenylate cyclase. The emitted donor accession is Q14833; it does not substitute for domain completeness in the target. Sequence analysis; class C signaling study.
The assessment concerns the selected accession A0A3B2WCZ5. Other emitted outputs and evidence context.