Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
RGD ISO annotations to rat from other mammalian species
p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor.
Stabilization and activation of p53 by the coactivator protein TAFII31.
Hyperthermia-induced apoptosis in two rat yolk sac tumor cell lines with different radiothermosensitivity in vitro.
Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation.
A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells.
Combinatorial control of the bradykinin B2 receptor promoter by p53, CREB, KLF-4, and CBP: implications for terminal nephron differentiation.
Polyamine depletion induces nucleophosmin modulating stability and transcriptional activity of p53 in intestinal epithelial cells.
Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen.
Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson's disease.
Multiple apoptotic pathways induced by p53-dependent acidification in benzo[a]pyrene-exposed hepatic F258 cells.
Subcellular localization of Daxx determines its opposing functions in ischemic cell death.
Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complex.
Niacin deficiency alters p53 expression and impairs etoposide-induced cell cycle arrest and apoptosis in rat bone marrow cells.
Glutamine supplementation prevents exercise-induced neutrophil apoptosis and reduces p38 MAPK and JNK phosphorylation and p53 and caspase 3 expression.
Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration.
Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment.
IFN-gamma promotes apoptosis of the uterus and placenta in pregnant rat and human cytotrophoblast cells.
Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cells.
A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2.
p53 expression and apoptosis in the lens after ultraviolet radiation exposure.
Retinoic acid downregulates microRNAs to induce abnormal development of spinal cord in spina bifida rat model.
p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC.
Activation of the p53-p21(Cip1) pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytes.
Differentially expressed pro- and anti-apoptogenic genes in response to benzene exposure: Immunohistochemical localization of p53, Bag, Bad, Bax, Bcl-2, and Bcl-w in lung epithelia.
Inhibition of p53 by pifithrin-alpha reduces myocyte apoptosis and leukocyte transmigration in aged rat hearts following 24 hours of reperfusion.
Effects of chronic treatment with valproate and oxcarbazepine on ovarian folliculogenesis in rats.
Hyperbaric oxygen attenuates apoptosis and decreases inflammation in an ischemic wound model.
Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease.
Analysis of p53 and NF-κB signaling in modulating the cardiomyocyte fate during hypertrophy.
Kinetics of GADD45α, TP53 and CASP3 gene expression in the rat lens in vivo in response to exposure to double threshold dose of UV-B radiation.
Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway.
Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes.
Role of reactive oxygen species in p53 activation during cisplatin-induced apoptosis of rat mesangial cells.
Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein.
Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine.
Spontaneous testicular atrophy occurs despite normal spermatogonial proliferation in a Tp53 knockout rat.
CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.
Physical and functional interaction between WT1 and p53 proteins.
Falcon (Edison Scientific) deep research report on rat Tp53 (P10361)
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Tp53 encodes p53, a conserved p53-family sequence-specific DNA-binding transcription factor that acts as a central stress-response node and tumor suppressor, binding p53 response elements to transcriptionally regulate gene programs (cell-cycle arrest, DNA repair, apoptosis, senescence) that determine cell fate under stress.
"**Tp53 encodes p53, a sequence-specific DNA-binding transcription factor** that acts as a central stress-response node and tumor suppressor (“guardian of the genome”) (wang2023targetingp53pathways pages 2-4, wang2023targetingp53pathways pages 1-2, shen2023targetingthep53 pages 1-2). Functionally, p53 binds p53 response elements in the genome and transcriptionally regulates gene programs that determine cell fate under stress, prominently including **cell-cycle arrest, DNA repair, apoptosis, and senescence**"
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p53 has a modular architecture with a central DNA-binding domain that mediates sequence-specific recognition of response elements, and an oligomerization domain; activated p53 forms tetramers, and tetramerization is required for efficient DNA binding and full transactivation.
"**Central DNA-binding domain (DBD)**: mediates sequence-specific recognition of response elements; this region is structurally characterized and highly conserved across vertebrates"
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Activated p53 forms tetramers and tetramerization is required for efficient DNA binding and full transactivation.
"**Oligomerization/tetramerization domain**: activated p53 forms tetramers; tetramerization is required for efficient DNA binding and full transactivation"
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Diverse cellular stresses, notably DNA damage, inhibit p53 ubiquitination, stabilize p53, and promote tetramer formation and DNA binding; the DNA damage response is the core pathway in which p53 acts, linking genotoxic/oncogenic stress to transcriptional reprogramming.
"Diverse cellular stresses (notably DNA damage) inhibit p53 ubiquitination, stabilize p53, and promote tetramer formation and DNA binding"
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p53 enforces cell-cycle arrest by transactivating CDKN1A/p21 and additional checkpoint mediators.
"**Cell-cycle arrest:** p53 transcriptionally activates CDKN1A/p21 and additional checkpoint mediators"
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p53 drives apoptosis by activating pro-apoptotic genes including PUMA, BAX and NOXA, and can also contribute through non-transcriptional mitochondrial mechanisms.
"**Apoptosis:** p53 activates pro-apoptotic genes including **PUMA, BAX, NOXA** and can also contribute through non-transcriptional mitochondrial mechanisms"
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p53 functions predominantly as a nuclear transcription factor, where stress-stabilized tetramers bind DNA response elements; it is also present in the cytoplasm and can relocalize to mitochondria for transcription-independent apoptotic signaling.
"**Nuclear:** stabilized p53 forms tetramers in the nucleus and binds DNA response elements to regulate transcription"
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A cytoplasmic/mitochondrial pool of p53 can trigger apoptosis through direct interactions with anti-apoptotic BCL-2 family members at mitochondria.
"**Cytoplasmic/mitochondrial:** p53 can trigger apoptosis through direct interactions with anti-apoptotic BCL-2 family members at mitochondria"
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Under basal conditions p53 abundance is kept low by MDM2/MDMX-mediated ubiquitination; MDM2 inhibits transactivation and promotes nuclear export and degradation, while p53 transcriptionally induces MDM2, forming an autoregulatory negative-feedback loop.
"MDM2 ubiquitinylates p53, inhibiting transactivation and promoting nuclear export and degradation; stress disrupts this interaction, stabilizing p53"
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p53 transcriptionally induces MDM2, yielding an autoregulatory negative feedback loop that shapes dynamics after DNA damage.
"p53 transcriptionally induces MDM2, yielding an autoregulatory negative feedback loop that shapes dynamics after DNA damage"
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Beyond the classic arrest/apoptosis/senescence triad, p53 also regulates metabolism, redox, autophagy, ferroptosis and tumor microenvironment interactions, and its outputs are context- and tissue-dependent.
"p53 also regulates **metabolism, redox, autophagy, ferroptosis, and tumor microenvironment interactions**"
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Rat-specific evidence: multiple p53 consensus elements occur in the TLR3 gene across species including Rattus norvegicus, and siRNA-mediated Tp53 silencing in rat lung CD117+ endothelial cells reduced Tlr3 and Id1 mRNA and increased angiogenic behavior, confirming a Tp53-dependent regulatory role in rat.
"**siRNA-mediated Tp53 silencing** in rat lung CD117+ endothelial cells reduced **Tlr3** and **Id1** mRNA and increased angiogenic behavior, indicating a Tp53-dependent regulatory role"