GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000118

TreeGrafter-generated GO annotations

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

file:PSEPK/katG/katG-uniprot.txt

UniProtKB Q88GQ0 KATG_PSEPK Pseudomonas putida KT2440

UniProt describes KatG as a bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.

"Bifunctional enzyme with both catalase and broad-spectrum"
UniProt records the catalatic reaction dismutating hydrogen peroxide to oxygen and water.

"Reaction=2 H2O2 = O2 + 2 H2O"
UniProt records the peroxidatic reaction reducing hydrogen peroxide using an organic electron donor.

"Reaction=H2O2 + AH2 = A + 2 H2O"
UniProt records heme b as the cofactor, with one heme b bound per dimer.

"Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer."
UniProt notes the Trp-Tyr-Met crosslink is required for the catalase but not the peroxidase activity.

"for the catalase, but not the peroxidase activity of the enzyme."

file:interpro/panther/PTHR30555/PTHR30555-metadata.yaml

PANTHER family PTHR30555 (HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE), subfamily PTHR30555:SF0 (CATALASE-PEROXIDASE)

katG (Q88GQ0) is classified in PANTHER family PTHR30555 and subfamily PTHR30555:SF0.
The PANTHER family and subfamily names confirm the bifunctional catalase-peroxidase function of KatG.

PMID:12534463

Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440

The KT2440 genome sequencing and annotation effort that established the PP_3668 (katG) locus and reference proteome entry.

file:PSEPK/katG/katG-notes.md

Curator notes for katG in Pseudomonas putida KT2440

Synthesis of UniProt evidence describing KatG as a central H2O2-scavenging enzyme in oxidative stress defense.

"central component of the cellular defense against oxidative/H2O2 stress."