Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
NXP-1, a human protein related to Rad21/Scc1/Mcd1, is a component of the nuclear matrix.
Human chromatid cohesin component hRad21 is phosphorylated in M phase and associated with metaphase centromeres.
Cohesin cleavage by separase required for anaphase and cytokinesis in human cells.
A potential role for human cohesin in mitotic spindle aster assembly.
Caspase proteolysis of the cohesin component RAD21 promotes apoptosis.
Linking sister chromatid cohesion and apoptosis: role of Rad21.
Processing, localization, and requirement of human separase for normal anaphase progression.
The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA.
Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.
Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.
Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts.
Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance.
The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells.
Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.
Wapl controls the dynamic association of cohesin with chromatin.
Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.
Protein requirements for sister telomere association in human cells.
Cohesin mediates transcriptional insulation by CCCTC-binding factor.
Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1.
Transcriptional dysregulation in NIPBL and cohesin mutant human cells.
The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells.
Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1.
Defining the membrane proteome of NK cells.
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
The hsSsu72 phosphatase is a cohesin-binding protein that regulates the resolution of sister chromatid arm cohesion.
Sororin mediates sister chromatid cohesion by antagonizing Wapl.
APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.
In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex.
HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.
A proteome-scale map of the human interactome network.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Architecture of the human interactome defines protein communities and disease networks.
Familial STAG2 germline mutation defines a new human cohesinopathy.
Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Cryo-EM structure of the human cohesin-NIPBL-DNA complex.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Structural basis of human separase regulation by securin and CDK1-cyclin B1.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Multimodal cell maps as a foundation for structural and functional genomics.
Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse.
Phosphorylation of cohesin by PLK1 at centromeres
PP2A-B56 dephosphorylates centromeric cohesin
Phosphorylation of cohesin by PLK1 at chromosomal arms
Resolution of sister chromatids
ESPL1 (Separase) cleaves centromeric cohesin
Separation of sister chromatids
Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2
Cohesin binds PDS5 and WAPAL
CDCA5 (Sororin) enables cohesion of sister chromosomal arms
CDK1 phosphorylates CDCA5 (Sororin) at centromeres
CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms
Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2
CDCA5 (Sororin) enables cohesion of sister centromeres
Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2
Deacetylation of cleaved cohesin
SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1
ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter
UniProt record for human RAD21 (O60216)
Deep research report for human RAD21 (falcon/Edison)
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RAD21 is the non-catalytic kleisin closure subunit of cohesin; RAD21 dosage alters NIPBL-MAU2 loader binding, loop extrusion, TAD/compartment contacts and transcription.
"Interphase cohesin extrudes chromatin loops until extrusion is halted or stabilized, frequently by convergently oriented CTCF sites."