Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Atp10p assists assembly of Atp6p into the F0 unit of the yeast mitochondrial ATPase.
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Atp10p cross-links to newly synthesized Atp6p on mitochondrial ribosomes
"following its synthesis on mitochondrial ribosomes, subunit 6 of the ATPase (Atp6p) can be cross-linked to Atp10p"
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The Atp10p-Atp6p interaction is required for integration of Atp6p into a partially assembled ATPase subcomplex
"This interaction is required for the integration of Atp6p into a partially assembled subcomplex of the ATPase"
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In an atp10 null mutant, Atp6p is less stable and more rapidly degraded
"Pulse labeling and chase of mitochondrial translation products in vivo indicate that Atp6p is less stable and more rapidly degraded in an atp10 null mutant than in wild type"
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Authors propose Atp10p is an Atp6p-specific chaperone facilitating Atp6p incorporation into the F0 sector
"we propose Atp10p to be an Atp6p-specific chaperone that facilitates the incorporation of Atp6p into an intermediate subcomplex of ATPase subunits"
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
ATP10, a yeast nuclear gene required for the assembly of the mitochondrial F1-F0 complex.
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ATP10 encodes a 30 kDa protein essential for assembly of a functional mitochondrial ATPase complex
"A yeast nuclear gene (ATP10) is reported whose product is essential for the assembly of a functional mitochondrial ATPase complex"
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Mutations in ATP10 cause loss of rutamycin sensitivity indicating defective F0 sector
"Mutations in ATP10 induce a loss of rutamycin sensitivity in the mitochondrial ATPase but do not affect respiratory enzymes. This phenotype has been correlated with a defect in the F0 sector of the ATPase"
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ATP10 product is not a subunit of the ATPase but is required for F0 assembly
"These data suggest that the ATP10 product is not a subunit of the ATPase complex but rather is required for the assembly of the F0 sector of the complex"
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The protein is associated with the mitochondrial membrane but does not co-fractionate with F1 or F1-F0
"The protein is associated with the mitochondrial membrane but does not co-fractionate either with F1 or with the rutamycin-sensitive F1-F0 complex"
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.
Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.
An inter-species protein-protein interaction network across vast evolutionary distance.
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Cross-species Y2H interaction reported between yeast Atp10p and human AGTRAP isoform 2; not physiologically relevant
"systematically probed the yeast and human proteomes for interactions between proteins from these two species and functionally characterized the resulting inter-interactome network"
Falcon deep research report on ATP10