Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
-
Keyword-based annotations for DNA binding, immunity, and innate immunity
"[UniProtKB keyword mapping]"
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Combined Automated Annotation using Multiple IEA Methods
Networks of bZIP protein-protein interactions diversified over a billion years of evolution.
-
Comprehensive bZIP dimerization network identified CEBP-2 interactions with multiple bZIP partners
"We studied the basic region-leucine zipper (bZIP) transcription factors and quantified bZIP dimerization networks for five metazoan and two single-cell species, measuring interactions in vitro for 2891 protein pairs"
-
CEBP-2 identified as highest-affinity binding partner for ZIP-11
"Metazoans have a higher proportion of heteromeric bZIP interactions and more network complexity than the single-cell species"
Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network.
-
Characterization of C. elegans transcription factor network interactions
"we comprehensively characterize such network rewiring for C. elegans transcription factors (TFs) within and across four newly delineated molecular networks"
CCAAT/enhancer-binding protein CEBP-2 controls fat consumption and fatty acid desaturation in Caenorhabditis elegans.
-
CEBP-2 loss-of-function causes low-fat phenotype
"loss of function of CEBP-2 displayed a low-fat phenotype in C. elegans owing to increased expression of ech-1.1 and decreased expression of fat-5"
-
CEBP-2 regulates ech-1.1 and fat-5 expression
"loss of function of CEBP-2 displayed a low-fat phenotype in C. elegans owing to increased expression of ech-1.1 and decreased expression of fat-5"
-
Controls fatty acid mitochondrial beta-oxidation and desaturation
"cebp-2 controls total body fat content by governing fatty acid mitochondrial beta-oxidation and desaturation in C. elegans"
The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity.
-
CEBP-2 is key player in surveillance immunity
"CEBP-2, the C. elegans ortholog of mammalian CCAAT-enhancer-binding protein gamma, is a key player in surveillance immunity"
-
Acts together with ZIP-2 in protective response to translational block by P. aeruginosa Exotoxin A
"CEBP-2 acts together with the bZIP transcription factor ZIP-2 in the protective response to translational block by P. aeruginosa Exotoxin A as well as perturbations of other processes"
-
Promotes survival upon P. aeruginosa infection
"CEBP-2 serves to limit pathogen burden, promote survival upon P. aeruginosa infection, and also promote survival upon Exotoxin A exposure"
A conserved mitochondrial surveillance pathway is required for defense against Pseudomonas aeruginosa.
-
CEBP-2 is part of bZIP family (with ZIP-2, ZIP-4, CEBP-1) mediating ESRE network
"family of bZIP proteins (including ZIP-2, ZIP-4, CEBP-1, and CEBP-2) that have overlapping and unique functions"
-
cebp-2;zip-2 double mutant shows significantly more death than single mutants
"The grey arrow indicates the cebp-2; zip-2 double mutant, which shows significantly more death than either single mutant"
The bZIP Transcription Factor ZIP-11 Is Required for the Innate Immune Regulation in Caenorhabditis elegans.
-
CEBP-2 physically interacts with ZIP-11 (shown by co-IP and GST pull-down)
"ZIP-11 and CEBP-2 can physically interact indeed. This interactive relationship was further revealed by GST pull-down assay"
-
ZIP-11 and CEBP-2 co-localize in intestinal nuclei upon P. aeruginosa infection
"these two bZIP transcription factors exist noticeable co-localization in intestinal nucleus of worms upon P. aeruginosa infection"
-
ZIP-11/CEBP-2 pathway mediates immune response independently of PMK-1/p38 pathway
"ZIP-11 interacts with a CCAAT/enhancer-binding protein, CEBP-2, to mediate the transcriptional response to P. aeruginosa PA14 infection"
-
cebp-2 RNAi abolishes the decreased survival phenotype of zip-11 mutants
"the decrease in survival upon P. aeruginosa infection of zip-11(tm4554) worms was abolished by cebp-2 RNAi"
Deep research report on cebp-2