Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

PMID:21802374

The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes.

ATG-2 binds EPG-6 directly; both are needed for omegasomes to progress to autophagosomes.

"epg-6 and atg-2 regulate progression of omegasomes to autophagosomes, and their loss of function causes accumulation of enlarged early autophagic structures"

PMID:25124690

PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation.

The ATG-2/EPG-6 complex acts upstream of MTM-3 and EPG-5.

"MTM-3 acts downstream of the ATG-2/EPG-6 complex and upstream of EPG-5 to promote autophagosome maturation into autolysosomes"

PMID:30952800

ATG2 transports lipids to promote autophagosome biogenesis.

Human ATG2A is a lipid transfer protein.

"ATG2A can bind tens of glycerophospholipids at once and transfers lipids robustly in vitro"

PMID:30911189

Atg2 mediates direct lipid transfer between membranes for autophagosome formation.

S. pombe Atg2 transfers phospholipids between tethered membranes.

"These results suggest that Atg2 acts as a lipid-transfer protein that supplies phospholipids for autophagosome formation"

PMID:30185561

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex.

ATG2A-WIPI4 complex structure; WIPI4 binds one tip of ATG2A.

"WIPI4 binds to one of the tips, enabling the ATG2A-WIPI4 complex to tether a PI3P-containing vesicle to another PI3P-free vesicle"

PMID:27396362

KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses.

atg-2 acts cell-autonomously in AIY neurons for presynaptic assembly.

"atg-2(bp576) (retrieval) mutants, retention of their"

file:worm/atg-2/atg-2-uniprot.txt

UniProt entry Q21480 (atg-2, C. elegans)

file:worm/atg-2/atg-2-deep-research-wormbase.md

WormBase gene description for atg-2 (worm)