Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC.
Mitochondria-derived and extra-mitochondrial human type-1 porin are identical as revealed by amino acid sequencing and electrophysiological characterisation.
Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1.
Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2.
The layered structure of human mitochondrial DNA nucleoids.
Structure of the human voltage-dependent anion channel.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase.
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system.
Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2.
Proteomic characterization of the human sperm nucleus.
PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.
Human Bop is a novel BH3-only member of the Bcl-2 protein family.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Aβ promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer's disease.
Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization.
Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop.
New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.
TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.
Architecture of the human interactome defines protein communities and disease networks.
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Deletion of Tmtc4 activates the unfolded protein response and causes postnatal hearing loss.
Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.
Ceramides bind VDAC2 to trigger mitochondrial apoptosis.
Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.
BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites.
Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase.
The microprotein SMIM26 connects metabolite transporters of the outer and inner mitochondrial membranes and is essential for respiratory chain function.
Subcellular localization of human voltage-dependent anion channel isoforms.
Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel.
Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria.
p62 links damaged mitochondria to LC3
LC3 binds the autophagosome membrane Atg5-Atg12 complex
p62 binds ubiquitinated mitochondrial substrates
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space
OPTN, TBK1 bind ubiquitinated MOM proteins
MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria
TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins
p-S-TBK1 phosphorylates OPTN
PRKN ubiquitinates MOM substrates
UniProtKB entry P21796 (VDAC1_HUMAN), Voltage-dependent anion-selective channel protein 1