Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure.

Myocardial contraction is 5-fold more economical in ventricular than in atrial human tissue.

Prevalence of cardiac beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy.

Myosin heavy chain composition and the economy of contraction in healthy and diseased human myocardium.

Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study.

Dissecting the N-terminal myosin binding site of human cardiac myosin-binding protein C. Structure and myosin binding of domain C2.

Mutations in the beta-myosin rod cause myosin storage myopathy via multiple mechanisms.

Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing.

The complete sequence of the human beta-myosin heavy chain gene and a comparative analysis of its product.

A proteome-scale map of the human interactome network.

Partial characterization of the human beta-myosin heavy-chain gene which is expressed in heart and skeletal muscle.

A reference map of the human binary protein interactome.

Abnormal contractile properties of muscle fibers expressing beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy.

Skeletal muscle expression and abnormal function of beta-myosin in hypertrophic cardiomyopathy.

Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy.

Myosin storage myopathy associated with a heterozygous missense mutation in MYH7.

Mutations in the slow skeletal muscle fiber myosin heavy chain gene (MYH7) cause laing early-onset distal myopathy (MPD1).

Mutations in sarcomere protein genes in left ventricular noncompaction.

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function.

Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly.

Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity.

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers.

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity.

Cryo-EM structure of the folded-back state of human β-cardiac myosin.

OpenScientist deep research report for human MYH7