Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones
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Established that spg-7 RNAi activates UPRmt hsp-6 and hsp-60 induction
"hsp-6 and hsp-60 induction was specific to perturbed mitochondrial protein handling, as neither heat-shock nor endoplasmic reticulum stress nor manipulations that impair mitochondrial steps in intermediary metabolism or ATP synthesis activated the mitochondrial chaperone genes"
A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans
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spg-7 identified as one of 212 genes affecting male tail tip morphogenesis
"Of the 41 suppressors of let-7 lethality identified by Ding et al. [44], six were positives in our screen. RNAi knockdown of two (pri-2, npp-6) resulted in the Ore phenotype, of two others (spg-7, smo-1) in the Lep phenotype"
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spg-7 RNAi causes Lep leptoderan phenotype
"RNAi knockdown of two (pri-2, npp-6) resulted in the Ore phenotype, of two others (spg-7, smo-1) in the Lep phenotype"
Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation
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spg-7 RNAi causes mitochondrial stress leading to ATFS-1 nuclear accumulation
"However, during mitochondrial stress, we found that import efficiency was reduced, allowing a percentage of ATFS-1 to accumulate in the cytosol and traffic to the nucleus"
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Established ATFS-1 import efficiency model for UPRmt regulation
"However, during mitochondrial stress, we found that import efficiency was reduced, allowing a percentage of ATFS-1 to accumulate in the cytosol and traffic to the nucleus"
Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection
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spg-7 RNAi activates UPRmt and innate immune genes via ATFS-1
"a number of transcripts induced during mitochondrial stress caused by inhibition of the mitochondrial protease SPG-7 encode innate immunity proteins"
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UPRmt pre-activation provides resistance to P. aeruginosa
"UPRmt pre-activation dramatically reduced the intestinal accumulation of P. aeruginosa expressing GFP"
Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).
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spg-7 RNAi reduces oxygen consumption indicating respiratory defects
"balanced ATFS-1 accumulation promoted OXPHOS complex assembly and function"
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ATFS-1 regulates OXPHOS gene expression during mitochondrial stress
"atfs-1 was required to limit the accumulation of OXPHOS transcripts during mitochondrial stress"
Falcon Research Report on spg-7 (worm)
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SPG-7 encodes conserved m-AAA metalloprotease subunit with AAA+ ATPase and M41 peptidase domains
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m-AAA proteases maintain protein quality, support mitochondrial ribosomal biogenesis and OXPHOS component maturation