Gene Ontology annotation through association of InterPro records with GO terms

InterPro2GO mapping electronically transfers GO terms (ADP/nucleotide binding, defense response) onto RPS2 from its NB-ARC/LRR InterPro signatures; useful as breadth, not as RPS2-specific evidence.

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

UniProt SubcellularLocation-to-GO mapping yields plasma membrane and cytoplasm localization terms for RPS2, consistent with its RIN4-guard role at the cytoplasmic face of the plasma membrane.

PMID:11204781

Mutational analysis of the Arabidopsis RPS2 disease resistance gene and the corresponding pseudomonas syringae avrRpt2 avirulence gene.

RPS2 encodes an NBS-LRR resistance protein that specifically recognizes Pseudomonas syringae strains expressing avrRpt2 and initiates a hypersensitive cell death response.

"The Arabidopsis RPS2 gene encodes a protein representative of the nucleotide-binding site-leucine-rich repeat (NBS-LRR) class of plant resistance proteins. RPS2 specifically recognizes Pseudomonas syringae pv. tomato strains expressing the avrRpt2 gene and initiates defense responses to bacteria carrying avrRpt2, including a hypersensitive cell death response (HR)."
Point mutations in conserved NBS and LRR motifs disrupt RPS2 resistance function, identifying these motifs as essential for the receptor's avrRpt2-triggered response.

"Ten novel rps2 alleles were characterized with mutations in the NBS and the LRR. Several of these alleles code for point mutations in motifs that are conserved among NBS-LRR resistance genes, including the third LRR, which suggests the importance of these motifs for resistance gene function."

PMID:11333251

The leucine-rich repeat domain can determine effective interaction between RPS2 and other host factors in arabidopsis RPS2-mediated disease resistance.

RPS2 LRR polymorphisms determine effective interaction with host factors required for avrRpt2-mediated resistance.

PMID:12581526

Initiation of RPS2-specified disease resistance in Arabidopsis is coupled to the AvrRpt2-directed elimination of RIN4.

RPS2 physically associates with RIN4 and initiates signaling when AvrRpt2 causes RIN4 elimination.

PMID:19682297

An F-box gene, CPR30, functions as a negative regulator of the defense response in Arabidopsis.

The cached source supports CPR30 defense regulation and CPR30-ASK protein interactions, but not direct RPS2 binding.

PMID:22331412

Structure-function analysis of the coiled-coil and leucine-rich repeat domains of the RPS5 disease resistance protein.

This citation is RPS5-centered and should not be used as direct RPS2-specific support.

PMID:26867179

Plant TRAF Proteins Regulate NLR Immune Receptor Turnover.

TRAF proteins regulate NLR immune receptor turnover, including RPS2-associated protein interactions.

PMID:8091210

RPS2 of Arabidopsis thaliana: a leucine-rich repeat class of plant disease resistance genes.

RPS2 encodes an LRR/NBS disease-resistance protein conferring resistance to Pseudomonas syringae strains expressing avrRpt2.

PMID:8986840

Molecular recognition of pathogen attack occurs inside of plant cells in plant disease resistance specified by the Arabidopsis genes RPS2 and RPM1.

RPS2/RPM1 recognition occurs inside plant cells, supporting intracellular localization of the recognition event.

DOI:10.1016/j.pmpp.2005.02.006

Identification and functional analysis of Arabidopsis proteins that interact with resistance gene product RPS2 in yeast.

This source reports candidate RPS2-interacting proteins but the generic protein binding term remains too broad for core functional curation.

file:ARATH/RPS2/RPS2-deep-research-falcon.md

Falcon deep research for Arabidopsis RPS2

RPS2 is a membrane-associated CNL immune receptor that detects AvrRpt2 activity indirectly through RIN4 cleavage/elimination.
RPS2 remains associated with a plasma-membrane RIN4 complex and triggers ETI, hypersensitive response, and restriction of Pseudomonas growth.

file:ARATH/RPS2/RPS2-uniprot.txt

UniProt record for Arabidopsis RPS2

UniProt identifies RPS2/Q42484 as a disease resistance NB-LRR protein with cytoplasmic and cell membrane localization annotations.

file:interpro/panther/PTHR33463/PTHR33463-entries.csv

PANTHER PTHR33463 plant disease resistance NBS-LRR family entries

PTHR33463 places Arabidopsis Q42484/RPS2 in an NB-ARC domain-containing disease-resistance protein family.