Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
UniProtKB entry O00217 (NDUS8_HUMAN)
Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns.
The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.
Differences in assembly or stability of complex I and other mitochondrial OXPHOS complexes in inherited complex I deficiency.
Late-onset Leigh syndrome in a patient with mitochondrial complex I NDUFS8 mutations.
Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing.
Architecture of Human Mitochondrial Respiratory Megacomplex I(2)III(2)IV(2).
Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes.
Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Genomic structure of the human NDUFS8 gene coding for the iron-sulfur TYKY subunit of the mitochondrial NADH:ubiquinone oxidoreductase.
The first nuclear-encoded complex I mutation in a patient with Leigh syndrome.
cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2
NUBPL transfers 4Fe-4S to Complex I subunits
Intermediate 1 binds HP subcomplex to form Intermediate 2
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I
ND4, ND5 bind the 550kDa complex to form the 815kDa complex
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex
IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1
NDUF subunits bind to form the IP subcomplex