GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

InterPro2GO mapping from A2M domains inappropriately assigns endopeptidase inhibitor activity to insect TEPs which have divergent complement-like opsonin function.

GO_REF:0000043

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Immunity keyword mapping to immune system process is appropriate for TEP family members.

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

file:ANOGA/TEP6/TEP6-deep-research-falcon.md

Deep research summary for TEP6 in Anopheles gambiae

TEP6 belongs to the insect thioester-containing protein family that functions in complement-like immunity, not as protease inhibitors like vertebrate A2M proteins.

"TEP1 is expressed in the fat body, circulates in hemolymph, and binds parasites in its cleaved form"
TEP6 shows evolutionary mosaicism with TEP1 through gene conversion, supporting functional relatedness within the complement-like TEP family.

"TEP1's sequence mosaicism reflects gene conversion with TEP6-like and TEP5-like sequences"
No direct experimental characterization of TEP6 exists; function is inferred from family membership and domain architecture.

"No TEP6-specific RNAi/knockout phenotype was recovered in the sources retrieved here"