Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling.
Stimulation by toll-like receptors inhibits osteoclast differentiation.
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.
Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs.
Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.
Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.
The dsRNA binding site of human Toll-like receptor 3.
Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling.
Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells.
Integral and associated lysosomal membrane proteins.
Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA.
The TLR3 signaling complex forms by cooperative receptor dimerization.
Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9.
Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms.
Isolated Toll-like receptor transmembrane domains are capable of oligomerization.
Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation.
Toll-like receptor 3 transmembrane domain is able to perform various homotypic interactions: an NMR structural study.
WDFY1 mediates TLR3/4 signaling by recruiting TRIF.
Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus.
Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes.
HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.
Chikungunya virus infection induces differential inflammatory and antiviral responses in human monocytes and monocyte-derived macrophages.
Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
The Src-ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage.
A family of human receptors structurally related to Drosophila Toll.
Full-length TLR3/7/8/9 binds to UNC93B1
UNC93B1 delivers endosomal full-length TLRs to endolysosome
Endosomal TLRs pass through the Golgi
Viral dsRNA binds the Toll-Like Receptor 3 (TLR3)
Viral dsRNA:TLR3 recruits TRIF (TICAM1)
Viral dsRNA:TLR3:TRIF complex recruits RIP1
Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
Activation of recruited TAK1 within the activated TLR3 complex
Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6
Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex
Defective TLR3 does not bind viral dsRNA
Defective TRAF3 does not transmit the signal
TICAM1 deficiency blocks TLR3 pathway
Defective UNC93B1 does not bind TLR3
Phosphorylated TAK1 dissociates from the TLR3 receptor complex
TLR3-induced ripoptosome assembly
Caspase-8 processing within TLR3 complex
RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis
Auto-ubiquitination of TRAF3 within activated TLR3 complex
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA
TRAF3 binds to TRIF:activated TLR3 complex
SARM binds viral dsRNA:TLR3:TICAM1
K63-linked ubiquitination of RIP1 bound to the activated TLR complex
IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation
TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3
IKKε (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3
TBK1 is phosphorylated within the activated TLR3 complex
OPTN binds TBK1 within the activated TLR3 complex
IKKε (IKBKE) is phosphorylated within the activated TLR3 complex
IKKε (IKBKE) is ubiquitinated within the activated TLR3 complex
TLR3 deficiency in patients with herpes simplex encephalitis.
Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling.
Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH.