GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:8576172

The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity.

P58IPK/DNAJC3 is a TPR-family protein that complexes with PKR (EIF2AK2) and inhibits both PKR autophosphorylation and PKR-catalyzed phosphorylation of eIF-2-alpha.

PMID:8666242

Cloning, expression, and cellular localization of the oncogenic 58-kDa inhibitor of the RNA-activated human and mouse protein kinase.

p58IPK/DNAJC3 was cloned and localized to the cytoplasm; widely expressed with high levels in pancreas and testis.

PMID:12601012

P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling.

P58IPK/DNAJC3 is induced by ER stress and acts as a negative regulator of eIF2-alpha signaling.

PMID:22064321

ERp29 induces breast cancer cell growth arrest and survival through modulation of activation of p38 and upregulation of ER stress protein p58IPK.

p58IPK/DNAJC3 is up-regulated downstream of ERp29-induced growth arrest; cited for negative regulation of translation and apoptosis but the link to DNAJC3 is correlative.

PMID:19199708

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).

PMID:19946888

Defining the membrane proteome of NK cells.

PMID:24769233

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.

PMID:25466870

Absence of BiP co-chaperone DNAJC3 causes diabetes mellitus and multisystemic neurodegeneration.

Loss of the BiP co-chaperone DNAJC3 causes an autosomal-recessive syndrome of juvenile-onset diabetes mellitus with multisystem neurodegeneration (ataxia, neuropathy, hearing loss).

Reactome:R-HSA-1791157

Reactome annotation (ER lumen localization of DNAJC3)

Reactome:R-HSA-6798751

Neutrophil degranulation (Reactome)

Reactome:R-HSA-8952289

Reactome annotation (ER lumen localization of DNAJC3)

Reactome:R-HSA-9835454

PKR-mediated signaling (Reactome)