Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase.
Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis.
Towards a proteome-scale map of the human protein-protein interaction network.
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.
A proteome-scale map of the human interactome network.
A reference map of the human binary protein interactome.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Zeta, a novel class of glutathione transferases in a range of species from plants to humans.
Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue.
UniProtKB entry O43708 (GSTZ1/MAAI, Homo sapiens)
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UniProt records the maleylacetoacetate isomerase reaction for O43708 with experimental evidence from PubMed:10739172.
"Reaction=4-maleylacetoacetate = 4-fumarylacetoacetate;"
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Glutathione is a required cofactor for the MAAI activity.
"Note=Glutathione is required for the MAAI activity."
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The enzyme is a homodimer, established by crystallography.
"Homodimer. {ECO:0000269|PubMed:11327815}."
PAINT IBD nodes for PANTHER family PTHR42673 (maleylacetoacetate isomerase)
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The maleylacetoacetate isomerase, glutathione transferase and glutathione metabolic process IBAs on GSTZ1 descend from the family-root IBD node PTN001344486, whose seeds include GSTZ1 itself; the mitochondrion IBA descends from node PTN000137159 (spanning animals, fungi and Dictyostelium), seeded only by human, mouse and rat GSTZ1/Gstz1.
"PTN000137159 GO:0005739 C IBD"
GST dimers conjugate GSH with cytosolic substrates
GSTZ1 dimer dehalogenates DCA