Vwf (mouse, UniProt Q8CIZ8) - manual literature research

No deep-research provider was available for this session; this file records the
literature work done manually from cached publications (publications/PMID_*.md),
the UniProt record (Vwf-uniprot.txt) and PubMed searches. Quotes are verbatim from
the cited source.

Identity and domain architecture

• Mouse von Willebrand factor, 2813 aa precursor (Swiss-Prot Q8CIZ8; MGI:98941;
  GeneID 22371). The precursor is cleaved into the propeptide "von Willebrand
  antigen 2" (residues 23-763) and mature VWF (764-2813) [file:mouse/Vwf/Vwf-uniprot.txt].
• Domains: VWFD1-D4, TIL, three VWFA domains (A1 "binding site for platelet
  glycoprotein Ib"; A3 "principal binding site for collagens type I and III"), VWFC
  and a C-terminal cystine knot (CTCK); RGD "Cell attachment site" at 2507-2509
  [file:mouse/Vwf/Vwf-uniprot.txt].
• UniProt function (by similarity to human P04275 and PMID:10930441): "it promotes
  adhesion of platelets to the sites of vascular injury by forming a molecular bridge
  between sub-endothelial collagen matrix and platelet-surface receptor complex
  GPIb-IX-V" and "Also acts as a chaperone for coagulation factor VIII".

Mouse genetic evidence

• Vwf knockout (Denis et al. 1998) PMID:9689113; FVIII reduced PMID:9689113. Abstract only in cache.
• Arteriolar thrombosis (Ni et al. 2000, full text) PMID:10930441
  and PMID:10930441.
• Venous platelet adhesion to VWF secreted on stimulated endothelium via GPIbalpha
  PMID:11071623.
• Laser injury: VWF is needed for platelet accumulation but not platelet activation
  PMID:17380206.
• VWF-GPIb-V-IX triggers platelet procoagulant activity / fibrin formation at low shear,
  impaired with Vwf-/- mouse plasma PMID:21037087.
• Weibel-Palade body formation requires VWF PMID:11274431; leukocyte rolling is reduced in Vwf-/- mice
  PMID:11274431.
• Atherosclerosis reduced in LDLR-/-Vwf-/- mice PMID:11520791.
• Tspan18-knockout mice: histamine-induced VWF release reduced (VWF measured as a
  readout) PMID:30573509.
• MAGP1 (Mfap2) binds VWF PMID:18281502.

Mechanism (from human VWF literature, cached)

• A1-GPIbalpha PMID:15039442.
• Integrin alphaIIb-beta3 via RGD PMID:24928861.
• Collagen binding PMID:2056120.
• FVIII carrier PMID:9759493.
• Multimerization PMID:17895385.
• ADAMTS13 substrate PMID:16221672.
• BiP ("heavy chain binding protein") association during biosynthesis
  PMID:3121636.

Problem references in GOA

• PMID:7854452 (Schmidt et al. 1995) is the Hgf (scatter factor) knockout paper; the
  GOA rows (liver/placenta development) carry the Hgf allele MGI:1857656
  (Hgf, checked on the MGI allele page) in With/From.
• PMID:8562500 is about CD24 (heat-stable antigen) as a P-selectin ligand; the abstract
  does not mention VWF.
• PMID:20097747 (requested for this session) is a rat myocardial infarction study in
  which an anti-vWF antibody is only an endothelial/capillary marker PMID:20097747; it gives no information about Vwf function.