Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Gene Ontology annotation of human sequence-specific DNA binding transcription factors based on the TFClass database

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase.

The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP).

ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene.

All roads lead to ATF4.

SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia.

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.

Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4).

Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements.

Roles of CHOP/GADD153 in endoplasmic reticulum stress.

ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome.

Mitosin/CENP-F as a negative regulator of activating transcription factor-4.

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.

The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism.

FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice.

A human protein-protein interaction network: a resource for annotating the proteome.

Towards a proteome-scale map of the human protein-protein interaction network.

p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain.

Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element.

Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene.

The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4.

ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation.

Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection.

C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene.

Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress.

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells.

Shifted Transversal Design smart-pooling for high coverage interactome mapping.

Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays.

An atlas of combinatorial transcriptional regulation in mouse and man.

Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.

A human MAP kinase interactome.

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress.

New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform.

Toward an understanding of the protein interaction network of the human liver.

The unfolded protein response: integrating stress signals through the stress sensor IRE1α.

The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway.

The endoplasmic reticulum stress response in aging and age-related diseases.

Effects of ATF4 on PGC1α expression in brown adipose tissue and metabolic responses to cold stress.

Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response.

ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin.

Networks of bZIP protein-protein interactions diversified over a billion years of evolution.

Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib.

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

A proteome-scale map of the human interactome network.

Widespread macromolecular interaction perturbations in human genetic disorders.

Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid cancer cells.

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

An inter-species protein-protein interaction network across vast evolutionary distance.

Combinatorial bZIP dimers display complex DNA-binding specificity landscapes.

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

Architecture of the human interactome defines protein communities and disease networks.

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.

An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.

ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis.

HENA, heterogeneous network-based data set for Alzheimer's disease.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.

Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.

A reference map of the human binary protein interactome.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.

QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4).

ZIP kinase, a novel serine/threonine kinase which mediates apoptosis.

Reactome pathway involving ATF4.

Reactome pathway involving ATF4.

Reactome pathway involving ATF4.

Reactome pathway involving ATF4.

Reactome pathway involving ATF4.

Reactome pathway involving ATF4.

Deep research review of ATF4 function (Cyberian provider)

A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response

The integrated stress response

Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.

Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress Response

Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver

Regulation of autophagy by ATF4 in response to severe hypoxia

Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression

Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA.

The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2

The transcription factor network associated with the amino acid response in mammalian cells

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress.

Transcription Factor C/EBP Homologous Protein in Health and Diseases.

Importin-mediated retrograde transport of CREB2 from distal processes to the nucleus in neurons.

Translational regulation of GCN4 and the general amino acid control of yeast

Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins

General amino acid control in fission yeast is regulated by a nonconserved transcription factor with functions analogous to Gcn4/Atf4