Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
Ring finger protein 166 potentiates RNA virus-induced interferon-β production via enhancing the ubiquitination of TRAF3 and TRAF6.
RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy.
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RNF166 is a catalytic RING E3 ligase that directly ubiquitinates SQSTM1/p62 via K29/K33-linked chains (at K91/K189), is required for early recruitment of ubiquitin, p62 and NDP52 to cytosolic bacteria, and restricts intracellular replication of Listeria and Shigella; the RING ligase-dead mutant (C33A/C36A) abolishes p62 ubiquitination.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.