Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes.
Patched1 interacts with cyclin B1 to regulate cell cycle progression.
Active cyclin B1-Cdk1 first appears on centrosomes in prophase.
A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels.
A novel UbcH10-binding protein facilitates the ubiquitinylation of cyclin B in vitro.
Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint.
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.
Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1.
Cyclin B and cyclin A confer different substrate recognition properties on CDK2.
Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development.
Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis.
cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner.
CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor.
Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development.
Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition.
Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation.
Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway.
Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.
NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity.
The protein interaction landscape of the human CMGC kinase group.
Sulforaphane induced cell cycle arrest in the G2/M phase via the blockade of cyclin B1/CDC2 in human ovarian cancer cells.
Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.
Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Sulforaphane, a Dietary Isothiocyanate, Induces G₂/M Arrest in Cervical Cancer Cells through CyclinB1 Downregulation and GADD45β/CDC2 Association.
Architecture of the human interactome defines protein communities and disease networks.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Structural basis of human separase regulation by securin and CDK1-cyclin B1.
A protein interaction landscape of breast cancer.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Cyclin-binding motifs are essential for the function of p21CIP1.
The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex.
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes
Formation of Cyclin B:Cdc2 complexes
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm
CAK phosphorylates CDK1 bound to CCNB1
Phosphorylation of Cyclin B1 in the CRS domain
Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
Free APC/C phosphorylated by Cyclin B:Cdc2
Degradation of multiubiquitinated Cyclin B
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
Phosphorylation of Cdh1 by Cyclin B1:Cdc2
CDK1 phosphorylates condensin II subunit NCAPD3
CDK1 phosphorylates CDCA5 (Sororin) at centromeres
CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms
CDK1:CCNB phosphorylates NEK9
CDK1 phosphorylates NUP98
CCNB1:p-T160-CDK1 phosphorylates NUMA1
CCNB:CDK1 phosphorylates BORA
CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1
FOXM1 stimulates CCNB1 transcription
CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments
SFN dimer binds CDK1 and CCNB1
CDK1 phosphorylates RUNX2
NPM1-ALK and FOXM1-dependent CCNB1 gene expression
MITF-M-dependent CCNB1 gene expression
Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB
CDK1 phosphorylates Mastl
Falcon deep-research report for human CCNB1 (P14635)