Gene Ontology annotation through association of InterPro records with GO terms
-
InterPro-based annotation projected a generic protein heterodimerization activity term to ABTB2 from domain associations.
"The ABTB2 GOA record includes an IEA annotation to GO:0046982 protein heterodimerization activity with GO_REF:0000002 as the source reference."
Gene Ontology annotation based on curation of immunofluorescence data
A central chaperone-like role for 14-3-3 proteins in human cells.
-
ABTB2 was identified as an interactor of 14-3-3 epsilon (YWHAE) in a systematic mapping of human 14-3-3 paralog interactomes.
"Here, we map the interactomes of all human 14-3-3 paralogs"
Mechanistic and functional characterization of ABTB2 as a novel target for pancreatic cancer therapy.
-
ABTB2 interacts with TRAP1 and promotes TRAP1 ubiquitination-dependent degradation in pancreatic cancer models.
"Transcriptomic analysis, immunoprecipitation, and functional assays demonstrated that ABTB2 interacts with tumour necrosis factor receptor-associated protein 1 (TRAP1), promoting its ubiquitin-dependent degradation"
-
The authors report that ABTB2 also interacts with cullin-3, supporting a substrate-adaptor-like model.
"We also found that ABTB2 interacts with cullin-3 (Figure S9)"
UniProt record for ABTB2 (Q8N961)
Proteostasis PN projected annotation report
-
The Proteostasis PN projection places ABTB2 in the Cul3 substrate-receptor branch and projects GO:1990756.
"ABTB2 Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|ankyrin"
Manual deep research fallback for ABTB2 PN review
-
Manual fallback review supports accepting GO:1990756 for ABTB2 based on direct ABTB2-TRAP1 ubiquitination/degradation and reported ABTB2-cullin-3 interaction.
"Direct ABTB2 evidence supports a substrate-adaptor-like role for TRAP1 ubiquitination-dependent degradation."