Subcellular localization of the yeast proteome
Proteome survey reveals modularity of the yeast cell machinery
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones
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Sqt1 is a dedicated chaperone for Rpl10 and shields Rpl10's N-terminal rRNA-binding residues during incorporation into pre-60S subunits.
"Affinity purification of four chaperones (Rrb1, Syo1, Sqt1 and Yar1) selectively enriched the mRNAs encoding their specific ribosomal protein clients (Rpl3, Rpl5, Rpl10 and Rps3). X-ray crystallography reveals how the N-terminal, rRNA-binding residues of Rpl10 are shielded by Sqt1's WD-repeat beta-propeller."
An inter-species protein-protein interaction network across vast evolutionary distance
The social and structural architecture of the yeast protein interactome
SQT1, which encodes an essential WD domain protein of Saccharomyces cerevisiae, suppresses dominant-negative mutations of the ribosomal protein gene QSR1
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Sqt1 is required for late 60S subunit assembly or modification in the cytoplasm.
"Loss of SQT1 function by down regulation from an inducible promoter results in formation of half-mer polyribosomes and decreased Qsr1p levels on free 60S subunits."
Falcon deep research report for SQT1
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Falcon supports SQT1 as a cytosolic Rpl10 carrier chaperone required for late 60S maturation and ribosome homeostasis.
"Sqt1 is an essential cytoplasmic WD40-repeat beta-propeller protein that functions as a dedicated chaperone/escortin for ribosomal protein Rpl10/uL16."