Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Purification and characterization of human Syk produced using a baculovirus expression system.
Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling.
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.
SPAP2, an Ig family receptor containing both ITIMs and ITAMs.
A role for Syk-kinase in the control of the binding cycle of the beta2 integrins (CD11/CD18) in human polymorphonuclear neutrophils.
Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites.
Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain.
Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.
Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase.
A quantitative protein interaction network for the ErbB receptors using protein microarrays.
SLP-65 signal transduction requires Src homology 2 domain-mediated membrane anchoring and a kinase-independent adaptor function of Syk.
Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells.
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates.
The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development.
Molecular mechanism of the Syk activation switch.
The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells.
Dectin-1 is required for human dendritic cells to initiate immune response to Candida albicans through Syk activation.
FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.
STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress.
A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets.
Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.
A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function.
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Next-generation sequencing to generate interactome datasets.
The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2.
Phospholipase Cγ2 (PLCγ2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses.
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome.
Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals.
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.
Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros.
Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation.
SYK is a critical regulator of FLT3 in acute myeloid leukemia.
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
Human intestinal epithelial cells respond to β-glucans via Dectin-1 and Syk.
A proteome-scale map of the human interactome network.
Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization.
Phospho-tyrosine dependent protein-protein interaction network.
Syk negatively regulates TLR4-mediated IFNβ and IL-10 production and promotes inflammatory responses in dendritic cells.
TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.
ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.
Roles of tau protein in health and disease.
SYK kinase mediates brown fat differentiation and activation.
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.
Physical proximity and functional cooperation of glycoprotein 130 and glycoprotein VI in platelet membrane lipid rafts.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.
A reference map of the human binary protein interactome.
Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice.
Tyrosine phosphorylation of DEPTOR functions as a molecular switch to activate mTOR signaling.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling.
TLR9 signaling requires ligand-induced phosphorylation of two specific tyrosine residues by EGFR and Syk.
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk.
Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance.
Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.
Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.
CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation.
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.
Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22.
Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk.
Identification of the site in the Syk protein tyrosine kinase that binds the SH2 domain of Lck.
Interaction of phosphorylated FcepsilonRIgamma immunoglobulin receptor tyrosine activation motif-based peptides with dual and single SH2 domains of p72syk. Assessment of binding parameters and real time binding kinetics.
Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain.
Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells.
Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
Binding of Syk tyrosine kinase
Phosphorylation and activation of PLCG
Recruitment of PLCgamma to membrane
PI3K phosphorylates PIP2 to PIP3
Release of PLCG from FCGR
Activation of RAC1 by VAV
Recruitment of SYK to phosphorylated ITAMs
Recruitment of VAV1 to p-6Y-SYK
Activation of RAC1 by CRKII:DOCK180:ELMO
Fcgamma receptor (FCGR) dependent phagocytosis
Recruitment of SYK to p-DAP12
Recruitment of CRKII:DOCK180:ELMO complex to FCGR
Phosphorylation of LAT by p-SYK
Phosphorylation of SLP-76 by p-SYK
PI3K phosphorylates PIP2 to PIP3
p85 regulatory unit of PI3K binds p-6Y-SYK
Phosphorylation of BTK by p-SYK
Phosphorylation and activation of VAV2/VAV3 by SYK
Phosphorylation of PLC-gamma by p-BTK/p-SYK
Fc epsilon receptor (FCERI) signaling
Recruitment of SYK to p-FCERI gamma subunit
Phosphorylation of TEC kinases by p-SYK
Phosphorylation of LAT by p-SYK
Phosphorylation of SLP-76 by p-SYK
Phosphorylation of NTAL by p-SYK/Lyn
Phosphorylation of SHC by SYK kinase
SYK binds to integrin alphaIIb beta3
Syk activation leads to SLP-76 activation
Syk/Lck phosphorylate LAT
GPVI stimulates PI3K beta, gamma
SYK is a substrate for JAK1
PLCG2 translocates from cytosol to plasma membrane
SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
SYK binds to p-Y65,Y76-FCER1G
C-type lectin receptors (CLRs)
p-Y7-CLEC1B dimer:PDPN binds SYK
Platelet activation, signaling and aggregation
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK
Recruitment of PLCgamma to membrane due to FCGR3A effect
Release of PLCG from FCGR3A
SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers
Phosphorylation and activation of PLCG due to FCGR3A effect
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
p-6Y-SYK phosphorylates VAV1,2,3
CRKII:DOCK180:ELMO binds FCGR3A
DOCK180 exchanges GTP for GDP on RAC1:GDP
p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP
VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
SYK binds the activated BCR
p-6Y-SYK phosphorylates BLNK (SLP65)
SYK autophosphorylates at the activated BCR
SYK binds p-Y15-Clec7a:1,3-beta-D-glucan
Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells.
Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.
CD14 controls the LPS-induced endocytosis of Toll-like receptor 4.
Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization.
Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.
BLNK: a central linker protein in B cell activation.
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs.
Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection.
The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen.
The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3.
Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros
Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130.
Bruton's tyrosine kinase is essential for hydrogen peroxide-induced calcium signaling.
Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase.
Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr.
CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex.
Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils.
Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12).
Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia
Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells.
TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption.
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome