Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Combined Automated Annotation using Multiple IEA Methods
Autophagy genes are essential for dauer development and life-span extension in C. elegans.
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BEC-1 is required for autophagy, dauer morphogenesis, and lifespan extension
"bec-1, the C. elegans ortholog of the yeast and mammalian autophagy gene APG6/VPS30/beclin1, is essential for normal dauer morphogenesis and life-span extension"
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Foundational paper establishing autophagy requirement in C. elegans longevity
"Dauer formation is associated with increased autophagy and also requires C. elegans orthologs of the yeast autophagy genes APG1, APG7, APG8, and AUT10"
Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans.
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BEC-1 is essential for development and necessary for VPS-34/LET-512 function
"BEC-1, the C. elegans ortholog of the yeast and mammalian autophagy proteins Atg6/Vps30 and Beclin 1, is essential for development"
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BEC-1 forms a complex with CED-9/BCL-2 and regulates apoptosis
"BEC-1 forms a complex with the antiapoptotic protein CED-9/Bcl-2, and its depletion triggers CED-3/Caspase-dependent PCD"
Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans.
Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans.
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bec-1 contributes to ion-channel-dependent neurotoxicity
"Inactivation of unc-51, bec-1 and lgg-1, the worm counterparts of the yeast autophagy genes Atg1, Atg6 and Atg8 respectively, partially suppresses degeneration of neurons with toxic ion channel variants"
Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation.
Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans.
Autophagy is required for dietary restriction-mediated life span extension in C. elegans.
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bec-1 is required for dietary restriction longevity in eat-2 mutants
"two essential autophagy genes (bec-1 and Ce-atg7) are required for the longevity phenotype of the C. elegans dietary restriction mutant"
The coiled-coil domain protein EPG-8 plays an essential role in the autophagy pathway in C. elegans.
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EPG-8 directly interacts with BEC-1
"EPG-8 directly interacts with the C. elegans Beclin 1 homolog, BEC-1"
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EPG-8 functions as C. elegans ATG14 homolog
"Our study demonstrates that epg-8 may function as a highly divergent homolog of the yeast autophagy gene Atg14"
The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans.
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BEC-1 functions in endosome-to-Golgi retrograde transport
"we report that BEC-1, the C. elegans ortholog of Atg6/Vps30/Beclin1, a key regulator of the autophagic machinery, also contributes to endosome function"
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BEC-1 is required for apoptotic corpse clearance
"We further identify a requirement for BEC-1 in the clearance of apoptotic corpses in the hermaphrodite gonad, suggesting a role for BEC-1 in phagosome maturation"
Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans.
Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
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BEC-1 is part of the PI3K complex that generates PtdIns3P
"SORF-1 and SORF-2 act in a complex with BEC-1/Beclin1"
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SORF-1 and SORF-2 interact with BEC-1 to regulate PI3K activity
"Loss of sorf-1 or sorf-2 leads to greatly elevated endosomal PtdIns3P, which drives excessive fusion of early endosomes"
A Non-Cell-Autonomous Role of BEC-1/BECN1/Beclin1 in Coordinating Cell-Cycle Progression and Stem Cell Proliferation during Germline Development.
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BEC-1 required for germline stem cell proliferation
"We found that autophagy genes such as bec-1/BECN1/Beclin1, atg-16.2/ATG16L, atg-18/WIPI1/2, and atg-7/ATG7 are required for the late larval expansion of germline stem cell progenitors"
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Acts non-cell-autonomously
"we report that BEC-1/BECN1/Beclin1 functions non-cell-autonomously to facilitate cell-cycle progression and stem cell proliferation"
Deep research on bec-1 gene function