Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4).
Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon.
Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex.
Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.
Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.
Y14 and hUpf3b form an NMD-activating complex.
A protein interaction framework for human mRNA degradation.
eIF4G is required for the pioneer round of translation in mammalian cells.
Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay.
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements.
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation.
NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity.
NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA.
Disassembly of exon junction complexes by PYM.
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.
A UPF3-mediated regulatory switch that maintains RNA surveillance.
Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export.
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.
The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA.
The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Nonsense-mediated mRNA decay: The challenge of telling right from wrong in a complex transcriptome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation.
Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)
Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)
Reactome: NMD/mRNA processing pathway step
Reactome: NMD/mRNA processing pathway step (cytosol localization)
Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)
Reactome: NMD/mRNA processing pathway step (cytosol localization)
Reactome: NMD/mRNA processing pathway step (cytosol localization)
Reactome: NMD/mRNA processing pathway step (cytosol localization)
Reactome: NMD/mRNA processing pathway step (cytosol localization)
Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)
Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)
Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)
Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)
Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)